GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Sod1 | affects localization | ISO | SOD1 (Homo sapiens) | 6480464 | CTD | tetrathiomolybdate analog affects the localization of SOD1 protein | PMID:19323979 | Sod1 | decreases activity | ISO | SOD1 (Homo sapiens) | 6480464 | CTD | tetrathiomolybdate results in decreased activity of SOD1 protein | PMID:18480265 | Sod1 | decreases expression | ISO | Sod1 (Rattus norvegicus) | 6480464 | CTD | tetrathiomolybdate results in decreased expression of SOD1 protein | PMID:21784888 | Sod1 | decreases expression | ISO | SOD1 (Homo sapiens) | 6480464 | CTD | tetrathiomolybdate analog results in decreased expression of SOD1 mRNA | PMID:19323979 | Sod1 | multiple interactions | ISO | SOD1 (Homo sapiens) | 6480464 | CTD | [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK1 protein]; [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK3 protein]; [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [IGF1 protein results in increased phosphorylation of MAPK1 protein]; [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [IGF1 protein results in increased phosphorylation of MAPK3 protein]; [tetrathiomolybdate results in decreased activity of SOD1 protein] which results in decreased abundance of Hydrogen Peroxide; [tetrathiomolybdate results in decreased activity of SOD1 protein] which results in increased abundance of Superoxides; Vanadates inhibits the reaction [[tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK1 protein]]; Vanadates inhibits the reaction [[tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK3 protein]] | PMID:18480265 | | ||||||||||||||||||||||
| Go Back to source page | Continue to Ontology report |