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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11329
Species: Mus musculus
RGD Object: Gene
Symbol: Sod1
Name: superoxide dismutase 1, soluble
Acc ID: CHEBI:29073
Term: L-ascorbic acid
Definition: The L-enantiomer of ascorbic acid and conjugate acid of L-ascorbate.
Chemical ID: MESH:D001205
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sod1affects abundanceEXP 6480464CTDSOD1 protein affects the abundance of Ascorbic AcidPMID:16377630
Sod1increases expressionEXP 6480464CTDAscorbic Acid results in increased expression of SOD1 mRNAPMID:32913121
Sod1increases expressionISOSOD1 (Homo sapiens)6480464CTDAscorbic Acid results in increased expression of SOD1 mRNAPMID:31576639 PMID:32913121
Sod1multiple interactionsISOSod1 (Rattus norvegicus)6480464CTD[alpha-Tocopherol co-treated with Ascorbic Acid] inhibits the reaction [arsenite results in increased expression of SOD1 protein]; [Ascorbic Acid co-treated with Vitamin E] inhibits the reaction [Diethylhexyl Phthalate results in increased expression of SOD1 protein]; Ascorbic Acid inhibits the reaction [Carbon Tetrachloride results in decreased activity of SOD1 protein]; Ascorbic Acid inhibits the reaction [chromium hexavalent ion results in decreased activity of SOD1 protein]; Ascorbic Acid inhibits the reaction [Lead results in decreased expression of SOD1 protein]; Ascorbic Acid inhibits the reaction [Potassium Dichromate results in decreased activity of SOD1 protein]; Ascorbic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of SOD1 mRNA]PMID:17822687 PMID:21344382 PMID:22056337 PMID:23470461 PMID:29663635 PMID:30676168
Sod1multiple interactionsISOSOD1 (Homo sapiens)6480464CTD[Ascorbic Acid co-treated with Vitamin E] results in increased expression of SOD1 mRNA; [Tretinoin co-treated with Ascorbic Acid] results in increased expression of SOD1 mRNA; Ascorbic Acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of SOD1 mRNA]; Ascorbic Acid inhibits the reaction [Hydrogen Peroxide results in decreased activity of SOD1 protein]PMID:16443354 PMID:22207723 PMID:28285367 PMID:31610155
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