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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11329
Species: Mus musculus
RGD Object: Gene
Symbol: Sod1
Name: superoxide dismutase 1, soluble
Acc ID: CHEBI:16796
Term: melatonin
Definition: A member of the class of acetamides that is acetamide in which one of the hydrogens attached to the nitrogen atom is replaced by a 2-(5-methoxy-1H-indol-3-yl)ethyl group. It is a hormone secreted by the pineal gland in humans.
Chemical ID: MESH:D008550
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sod1increases activityEXP 6480464CTDMelatonin results in increased activity of SOD1 proteinPMID:23554006
Sod1multiple interactionsEXP 6480464CTD[aluminum lactate co-treated with Melatonin] results in increased expression of SOD1 mRNA; luzindole inhibits the reaction [Melatonin results in increased activity of SOD1 protein]; Melatonin inhibits the reaction [Dibutyl Phthalate results in increased activity of SOD1 protein]PMID:19405147 PMID:19680607 PMID:23554006 PMID:37277016
Sod1increases expressionISOSod1 (Rattus norvegicus)6480464CTDMelatonin results in increased expression of SOD1 mRNAPMID:15589378 PMID:21442002
Sod1multiple interactionsISOSod1 (Rattus norvegicus)6480464CTD[aluminum lactate co-treated with Melatonin] results in increased expression of SOD1 mRNA; [Cadmium Chloride co-treated with Melatonin] results in increased expression of SOD1 mRNA; Melatonin inhibits the reaction [Indomethacin results in decreased activity of SOD1 protein]; Melatonin inhibits the reaction [isolevin results in increased expression of SOD1 protein]; Melatonin inhibits the reaction [Triiodothyronine, Reverse results in decreased activity of and results in decreased expression of SOD1 protein]; Melatonin inhibits the reaction [Triiodothyronine, Reverse results in decreased expression of SOD1 mRNA]PMID:11523592 PMID:15589378 PMID:17198541 PMID:20210856 PMID:21442002
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