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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11319
Species: Mus musculus
RGD Object: Gene
Symbol: Slc9a3
Name: solute carrier family 9 (sodium/hydrogen exchanger), member 3
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc9a3affects expressionEXP 6480464CTDTetrachlorodibenzodioxin affects the expression of SLC9A3 mRNAPMID:26377647
Slc9a3increases expressionISOSlc9a3 (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in increased expression of SLC9A3 mRNAPMID:32109520
Slc9a3multiple interactionsISOSLC9A3 (Homo sapiens)6480464CTD[[Defoliants, Chemical results in increased abundance of Agent Orange] which results in increased abundance of Tetrachlorodibenzodioxin] which results in decreased methylation of SLC9A3 genePMID:33849548
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