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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11300
Species: Mus musculus
RGD Object: Gene
Symbol: Slc18a2
Name: solute carrier family 18 (vesicular monoamine), member 2
Acc ID: CHEBI:28487
Term: reserpine
Definition: An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria.
Chemical ID: MESH:D012110
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc18a2affects response to substanceEXP 6480464CTDSLC18A2 affects the susceptibility to ReserpinePMID:17664021
Slc18a2affects bindingISOSlc18a2 (Rattus norvegicus)6480464CTDSLC18A2 protein binds to ReserpinePMID:9038139
Slc18a2affects bindingISOSLC18A2 (Homo sapiens)6480464CTDReserpine binds to SLC18A2 proteinPMID:7912402
Slc18a2decreases activityISOSlc18a2 (Rattus norvegicus)6480464CTDReserpine results in decreased activity of SLC18A2 proteinPMID:29908239
Slc18a2decreases activityISOSLC18A2 (Homo sapiens)6480464CTDReserpine results in decreased activity of SLC18A2 proteinPMID:15475732 PMID:33378168
Slc18a2decreases response to substanceISOSLC18A2 (Homo sapiens)6480464CTDSLC18A2 gene SNP results in decreased susceptibility to ReserpinePMID:15475732
Slc18a2increases expressionISOSlc18a2 (Rattus norvegicus)6480464CTDReserpine results in increased expression of SLC18A2 mRNAPMID:8189248
Slc18a2multiple interactionsISOSlc18a2 (Rattus norvegicus)6480464CTDReserpine inhibits the reaction [SLC18A2 protein results in increased uptake of Serotonin]; Serotonin inhibits the reaction [SLC18A2 protein binds to Reserpine]PMID:1438304 PMID:18287335 PMID:9038139
Slc18a2multiple interactionsISOSLC18A2 (Homo sapiens)6480464CTDReserpine inhibits the reaction [SLC18A2 protein results in increased uptake of Dopamine]PMID:29908239
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