GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Ccl2 | affects response to substance | EXP | | 6480464 | CTD | CCL2 affects the susceptibility to Streptozocin | PMID:16374426 | Ccl2 | increases expression | EXP | | 6480464 | CTD | Streptozocin results in increased expression of CCL2; Streptozocin results in increased expression of CCL2 mRNA; Streptozocin results in increased expression of CCL2 protein | PMID:16374426 PMID:29266779 PMID:29420703 PMID:30184259 | Ccl2 | increases secretion | EXP | | 6480464 | CTD | Streptozocin results in increased secretion of CCL2 protein | PMID:21832210 | Ccl2 | multiple interactions | EXP | | 6480464 | CTD | 4-(4-(3-adamantan-1-ylureido)cyclohexyloxy)benzoic acid inhibits the reaction [Streptozocin results in increased secretion of CCL2 protein]; [AM6545 co-treated with Perindopril] inhibits the reaction [Streptozocin results in increased expression of CCL2 mRNA]; [AM6545 co-treated with Perindopril] inhibits the reaction [Streptozocin results in increased expression of CCL2 protein]; [Dietary Fats co-treated with Streptozocin] results in increased expression of CCL2 mRNA; [Dietary Fats co-treated with Streptozocin] results in increased expression of CCL2 protein; [fatostatin co-treated with Streptozocin] results in increased expression of CCL2 protein; [Streptozocin co-treated with Dietary Fats] results in increased secretion of CCL2 protein; bergenin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased secretion of CCL2 protein]; CEBPB protein inhibits the reaction [Streptozocin results in increased expression of CCL2 protein]; EPHX2 gene mutant form inhibits the reaction [Streptozocin results in increased secretion of CCL2 protein]; esculetin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of CCL2 protein]; Glucagon analog inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of CCL2 mRNA]; stannous mesoporphyrin inhibits the reaction [4-(4-(3-adamantan-1-ylureido)cyclohexyloxy)benzoic acid inhibits the reaction [Streptozocin results in increased secretion of CCL2 protein]]; Valsartan inhibits the reaction [Streptozocin results in increased expression of CCL2 protein] | PMID:21832210 PMID:27769711 PMID:29266779 PMID:29420703 PMID:29988851 PMID:30184259 PMID:37482253 | Ccl2 | increases expression | ISO | Ccl2 (Rattus norvegicus) | 6480464 | CTD | Streptozocin results in increased expression of CCL2 mRNA; Streptozocin results in increased expression of CCL2 protein | PMID:15284299 PMID:16684804 PMID:17624267 PMID:18413206 PMID:18999900 PMID:23611540 PMID:24513509 PMID:25199697 PMID:31696645 PMID:33639173 | Ccl2 | multiple interactions | ISO | Ccl2 (Rattus norvegicus) | 6480464 | CTD | [Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of CCL2 protein; dapagliflozin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of CCL2 protein]; diphenyldiselenide inhibits the reaction [Streptozocin results in increased expression of CCL2 mRNA]; Flavonoids inhibits the reaction [Streptozocin results in increased expression of CCL2 protein]; Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of CCL2 protein]; Metformin inhibits the reaction [Streptozocin results in increased expression of CCL2 mRNA]; moutan cortex inhibits the reaction [Streptozocin results in increased expression of and results in increased secretion of CCL2 protein]; Mycophenolic Acid inhibits the reaction [Streptozocin results in increased expression of CCL2 mRNA]; Mycophenolic Acid inhibits the reaction [Streptozocin results in increased expression of CCL2 protein]; PD 123319 inhibits the reaction [Streptozocin results in increased expression of CCL2 mRNA]; Pentoxifylline inhibits the reaction [Streptozocin results in increased expression of CCL2 protein]; procyanidin B2 inhibits the reaction [Streptozocin results in increased expression of CCL2 mRNA]; prolinedithiocarbamate inhibits the reaction [Streptozocin results in increased expression of CCL2 mRNA]; Resveratrol inhibits the reaction [Streptozocin results in increased expression of CCL2 protein]; Rosiglitazone inhibits the reaction [Streptozocin results in increased expression of CCL2 mRNA]; Streptozocin results in increased expression of and results in increased secretion of CCL2 protein; Valsartan inhibits the reaction [Streptozocin results in increased expression of CCL2 mRNA]; Valsartan inhibits the reaction [Streptozocin results in increased expression of CCL2 protein]; vanadyl sulfate inhibits the reaction [Streptozocin results in increased expression of CCL2 mRNA] | PMID:15284299 PMID:16684804 PMID:17624267 PMID:18413206 PMID:19921414 PMID:24513509 PMID:25199697 PMID:27664441 PMID:30551545 PMID:31696645 PMID:33639173 | | ||||||||||||||||||||||
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