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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11275
Species: Mus musculus
RGD Object: Gene
Symbol: Ccl2
Name: C-C motif chemokine ligand 2
Acc ID: CHEBI:46195
Term: paracetamol
Definition: A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Chemical ID: MESH:D000082
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccl2affects expressionEXP 6480464CTDAcetaminophen affects the expression of CCL2 mRNAPMID:17562736
Ccl2increases expressionEXP 6480464CTDAcetaminophen results in increased expression of CCL2 mRNA; Acetaminophen results in increased expression of CCL2 proteinPMID:11981759 PMID:12153990 PMID:14550746 PMID:14557383 PMID:15578514 PMID:16081117 PMID:16552707 PMID:19799668 PMID:20100502 PMID:20123758 PMID:22575169 PMID:25265579 PMID:26079055 PMID:30099449 PMID:31444509 PMID:31697998 PMID:34078832 PMID:36126895 PMID:36928416 PMID:37046119
Ccl2increases secretionEXP 6480464CTDAcetaminophen results in increased secretion of CCL2 proteinPMID:26079055
Ccl2multiple interactionsEXP 6480464CTD[Acetaminophen co-treated with Ozone] results in increased expression of CCL2 mRNA; [Ozone co-treated with Acetaminophen] results in increased expression of CCL2 protein; amlexanox inhibits the reaction [Acetaminophen results in increased expression of CCL2 mRNA]; Carnosine inhibits the reaction [Acetaminophen results in increased expression of CCL2 mRNA]; Carnosine inhibits the reaction [Acetaminophen results in increased expression of CCL2 protein]; CAV1 affects the reaction [Acetaminophen results in increased expression of CCL2 mRNA]; Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased expression of CCL2 mRNA]; Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased secretion of CCL2 protein]; fasudil inhibits the reaction [Acetaminophen results in increased expression of CCL2 protein]; IFNG protein promotes the reaction [Acetaminophen results in increased expression of CCL2 mRNA]; KLRB1C protein promotes the reaction [Acetaminophen results in increased expression of CCL2 mRNA]; MST1R protein affects the reaction [Acetaminophen results in increased expression of CCL2 mRNA]; Ozone inhibits the reaction [Acetaminophen results in increased expression of CCL2 mRNA]; P2RX1 protein affects the reaction [Acetaminophen results in increased expression of CCL2 mRNA]; P2RX1 protein affects the reaction [Acetaminophen results in increased expression of CCL2 protein]; PTGES2 protein promotes the reaction [Acetaminophen results in increased expression of CCL2 mRNA]; Rotenone inhibits the reaction [Acetaminophen results in increased expression of CCL2 mRNA]; saikosaponin D inhibits the reaction [Acetaminophen results in increased expression of CCL2 mRNA]; sappanone A inhibits the reaction [Acetaminophen results in increased expression of CCL2 mRNA]; TNFRSF1A protein promotes the reaction [Acetaminophen results in increased expression of CCL2 mRNA]; TNFRSF1A protein promotes the reaction [Acetaminophen results in increased expression of CCL2 protein]; vadimezan affects the reaction [P2RX1 protein affects the reaction [Acetaminophen results in increased expression of CCL2 mRNA]]; vadimezan affects the reaction [P2RX1 protein affects the reaction [Acetaminophen results in increased expression of CCL2 protein]]PMID:12153990 PMID:14550746 PMID:14557383 PMID:15578514 PMID:19799668 PMID:20100502 PMID:20123758 PMID:22575169 PMID:25265579 PMID:26079055 PMID:30099449 PMID:31444509 PMID:31697998 PMID:34078832 PMID:36126895 PMID:37046119
Ccl2affects expressionISOCcl2 (Rattus norvegicus)6480464CTDAcetaminophen affects the expression of CCL2 mRNAPMID:33387578
Ccl2decreases expressionISOCCL2 (Homo sapiens)6480464CTDAcetaminophen results in decreased expression of CCL2 mRNAPMID:21420995 PMID:29067470
Ccl2increases expressionISOCcl2 (Rattus norvegicus)6480464CTDAcetaminophen results in increased expression of CCL2 proteinPMID:16687475
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