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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11275
Species: Mus musculus
RGD Object: Gene
Symbol: Ccl2
Name: C-C motif chemokine ligand 2
Acc ID: CHEBI:3962
Term: curcumin
Definition: A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa.
Chemical ID: MESH:D003474
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccl2decreases expressionEXP 6480464CTDCurcumin results in decreased expression of CCL2 mRNA; Curcumin results in decreased expression of CCL2 proteinPMID:18403477
Ccl2multiple interactionsEXP 6480464CTDCurcumin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]PMID:20712904
Ccl2decreases expressionISOCcl2 (Rattus norvegicus)6480464CTDCurcumin results in decreased expression of CCL2 mRNAPMID:10925121 PMID:11053056
Ccl2increases expressionISOCCL2 (Homo sapiens)6480464CTDCurcumin results in increased expression of CCL2 mRNAPMID:17198877
Ccl2multiple interactionsISOCcl2 (Rattus norvegicus)6480464CTDCurcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of CCL2 mRNA]PMID:22683883
Ccl2multiple interactionsISOCCL2 (Homo sapiens)6480464CTDCurcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of CCL2 protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of CCL2 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of CCL2 protein]; MIR125A mRNA inhibits the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of CCL2 protein]]; SIRT6 protein promotes the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of CCL2 protein]]PMID:17666914 PMID:19152916 PMID:23452621 PMID:33952798
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