GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Ccl2 | increases expression | EXP | | 6480464 | CTD | Silicon Dioxide analog results in increased expression of CCL2 mRNA; Silicon Dioxide results in increased expression of CCL2 mRNA; Silicon Dioxide results in increased expression of CCL2 protein | PMID:19073995 PMID:23221170 PMID:25388157 PMID:27428020 PMID:29341224 PMID:31284023 PMID:33720480 | Ccl2 | increases secretion | EXP | | 6480464 | CTD | Silicon Dioxide results in increased secretion of CCL2 protein | PMID:22273745 PMID:23640035 PMID:29484482 | Ccl2 | multiple interactions | EXP | | 6480464 | CTD | [Gold co-treated with Silicon Dioxide] results in increased secretion of CCL2 protein; [Silicon Dioxide co-treated with Lipopolysaccharides] results in increased secretion of CCL2 protein; [SOD3 gene mutant form results in increased susceptibility to Silicon Dioxide] which results in increased expression of CCL2 mRNA; AHR protein affects the reaction [[Silicon Dioxide co-treated with Lipopolysaccharides] results in increased secretion of CCL2 protein]; AHR protein affects the reaction [Silicon Dioxide results in increased secretion of CCL2 protein]; GAS6 protein affects the reaction [Silicon Dioxide results in increased expression of CCL2 protein]; IL10 protein inhibits the reaction [[Silicon Dioxide co-treated with Lipopolysaccharides] results in increased secretion of CCL2 protein]; IL10 protein inhibits the reaction [AHR protein affects the reaction [[Silicon Dioxide co-treated with Lipopolysaccharides] results in increased secretion of CCL2 protein]]; IL1B protein affects the reaction [Silicon Dioxide analog results in increased expression of CCL2 mRNA]; IL1B protein affects the reaction [Silicon Dioxide results in increased secretion of CCL2 protein]; MERTK protein affects the reaction [Silicon Dioxide results in increased expression of CCL2 protein] | PMID:22155353 PMID:22273745 PMID:23640035 PMID:25388157 PMID:30453980 PMID:31284023 | Ccl2 | decreases secretion | ISO | CCL2 (Homo sapiens) | 6480464 | CTD | Silicon Dioxide results in decreased secretion of CCL2 protein | PMID:22300531 | Ccl2 | increases expression | ISO | Ccl2 (Rattus norvegicus) | 6480464 | CTD | Silicon Dioxide results in increased expression of CCL2 mRNA; Silicon Dioxide results in increased expression of CCL2 protein | PMID:21602193 PMID:22431001 PMID:22861000 | Ccl2 | increases expression | ISO | CCL2 (Homo sapiens) | 6480464 | CTD | Silicon Dioxide analog results in increased expression of CCL2 mRNA; Silicon Dioxide results in increased expression of CCL2 mRNA; Silicon Dioxide results in increased expression of CCL2 protein | PMID:23806026 PMID:25895662 PMID:26163174 PMID:29658397 | Ccl2 | multiple interactions | ISO | CCL2 (Homo sapiens) | 6480464 | CTD | CCR2 promotes the reaction [Silicon Dioxide results in increased secretion of CCL2 protein]; Silicon Dioxide inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of CCL2 protein] | PMID:26163174 PMID:36416909 | | ||||||||||||||||||||||
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