Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	11275
Species:	Mus musculus
RGD Object:	Gene
Symbol:	Ccl2
Name:	C-C motif chemokine ligand 2

Acc ID:	CHEBI:33234
Term:	vitamin E
Definition:	Any member of a group of fat-soluble chromanols that exhibit biological activity against vitamin E deficiency. The vitamers in this class consists of a chroman-6-ol core which is substituted at position 2 by a methyl group and (also at position 2) either a saturated or a triply-unsaturated hydrocarbon chain consisting of three isoprenoid units. The major function of vitamin E is to act as a natural antioxidant by scavenging free radicals and molecular oxygen.
Chemical ID:	MESH:D024502

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
Ccl2	increases expression	EXP		6480464	CTD	Vitamin E deficiency results in increased expression of CCL2 protein	PMID:19735175
Ccl2	multiple interactions	EXP		6480464	CTD	alpha-Tocopherol inhibits the reaction [Vitamin E deficiency results in increased expression of CCL2 protein]; Quercetin inhibits the reaction [Vitamin E deficiency results in increased expression of CCL2 protein]	PMID:19735175

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