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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11219
Species: Mus musculus
RGD Object: Gene
Symbol: Rb1
Name: RB transcriptional corepressor 1
Acc ID: CHEBI:18723
Term: nicotine
Definition: A racemate composed of equimolar amounts of (R)- and (S)-nicotine.
Chemical ID: MESH:D009538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Rb1increases phosphorylationEXP 6480464CTDNicotine results in increased phosphorylation of RB1 proteinPMID:15574422
Rb1decreases expressionISORB1 (Homo sapiens)6480464CTDNicotine results in decreased expression of RB1 proteinPMID:16011614
Rb1increases expressionISORB1 (Homo sapiens)6480464CTDNicotine results in increased expression of RB1 protein modified formPMID:20061081
Rb1increases phosphorylationISORB1 (Homo sapiens)6480464CTDNicotine results in increased phosphorylation of RB1 proteinPMID:16862215 PMID:18448488 PMID:18805435
Rb1multiple interactionsISORB1 (Homo sapiens)6480464CTD4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide inhibits the reaction [Nicotine results in increased phosphorylation of RB1 protein]; Aconitine analog inhibits the reaction [Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]]; ARRB1 protein affects the reaction [Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]]; Bungarotoxins inhibits the reaction [Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]]; CHRNA7 protein affects the reaction [Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]]; MK-886 inhibits the reaction [Nicotine results in increased expression of RB1 protein modified form]; Nicotine inhibits the reaction [RB1 protein binds to BIRC5 promoter]; Nicotine inhibits the reaction [RB1 protein binds to CDC25A promoter]; Nicotine inhibits the reaction [RB1 protein binds to CDC6 promoter]; Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]; SRC protein affects the reaction [Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]]PMID:16601104 PMID:16862215 PMID:18805435 PMID:20061081
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