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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11217
Species: Mus musculus
RGD Object: Gene
Symbol: Rarb
Name: retinoic acid receptor, beta
Acc ID: CHEBI:15367
Term: all-trans-retinoic acid
Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID: MESH:D014212
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Rarbincreases expressionEXP 6480464CTDTretinoin results in increased expression of RARB; Tretinoin results in increased expression of RARB mRNA; Tretinoin results in increased expression of RARB mRNA alternative formPMID:10600643 PMID:12834868 PMID:15688020 PMID:16038797 PMID:16199432 PMID:16291826 PMID:16604517 PMID:16613989 PMID:16723356 PMID:36189433 PMID:7864861 PMID:8838863 PMID:8892963
Rarbincreases response to substanceEXP 6480464CTDRARB protein results in increased susceptibility to TretinoinPMID:16860305
Rarbmultiple interactionsEXP 6480464CTD[DHRS3 gene mutant form results in increased abundance of Tretinoin] which results in increased expression of RARB mRNA; [mono-(2-ethylhexyl)phthalate co-treated with Tretinoin] results in increased expression of RARB mRNA; [Tretinoin binds to and results in increased activity of RARB protein] which results in increased expression of and results in increased activity of SHH protein; AKT1 protein inhibits the reaction [Tretinoin results in increased expression of RARB mRNA]; ALDH1A3 protein promotes the reaction [Tretinoin results in increased expression of RARB mRNA]; Anisomycin promotes the reaction [Tretinoin results in increased expression of RARB mRNA]; Arsenic Trioxide inhibits the reaction [Tretinoin results in increased expression of RARB mRNA]; MED1 protein affects the reaction [Tretinoin results in increased expression of RARB mRNA alternative form]; NCOA1 protein affects the reaction [Tretinoin results in increased expression of RARB mRNA alternative form]; RARA protein affects the reaction [Tretinoin affects the expression of RARB mRNA]; Tetrachlorodibenzodioxin inhibits the reaction [Tretinoin results in increased expression of RARB mRNA]; Tretinoin binds to and results in increased activity of RARB proteinPMID:12504905 PMID:15688020 PMID:16038797 PMID:16261163 PMID:16613989 PMID:16723356 PMID:16839186 PMID:16860305 PMID:17207476 PMID:24005908 PMID:36189433 PMID:7864861
Rarbaffects bindingISORARB (Homo sapiens)6480464CTDTretinoin binds to RARB proteinPMID:15958702 PMID:31195007
Rarbdecreases expressionISORARB (Homo sapiens)6480464CTDTretinoin results in decreased expression of RARB mRNAPMID:10673743 PMID:17034753
Rarbdecreases response to substanceISORARB (Homo sapiens)6480464CTDRARB gene modified form results in decreased susceptibility to Tretinoin; RARB protein alternative form results in decreased susceptibility to TretinoinPMID:16287870 PMID:17001699
Rarbincreases activityISORARB (Homo sapiens)6480464CTDTretinoin results in increased activity of RARB proteinPMID:25492813
Rarbincreases expressionISORarb (Rattus norvegicus)6480464CTDTretinoin results in increased expression of RARB mRNA; Tretinoin results in increased expression of RARB mRNA alternative form; Tretinoin results in increased expression of RARB proteinPMID:11171635 PMID:15708448 PMID:19450544 PMID:20488242 PMID:26672737
Rarbincreases expressionISORARB (Homo sapiens)6480464CTDTretinoin metabolite results in increased expression of RARB mRNA; Tretinoin results in increased expression of RARB; Tretinoin results in increased expression of RARB mRNA; Tretinoin results in increased expression of RARB mRNA alternative form; Tretinoin results in increased expression of RARB protein; Tretinoin results in increased expression of RARB protein alternative formPMID:10866818 PMID:10953040 PMID:11029503 PMID:11133770 PMID:12839938 PMID:15317450 PMID:15375546 PMID:15754000 PMID:15959780 PMID:16012519 PMID:16184197 PMID:16287870 PMID:16289102 PMID:16613989 PMID:16646664 PMID:16832676 PMID:16959971 PMID:17079450 PMID:17134824 PMID:17138961 PMID:17431108 PMID:17453147 PMID:17486130 PMID:18941112 PMID:19142034 PMID:20507312 PMID:21393419 PMID:21934132 PMID:22906706 PMID:23724009 PMID:24819975 PMID:25492813 PMID:25725299 PMID:30076181 PMID:33167477 PMID:35483669 PMID:36805303 PMID:7556191
Rarbincreases response to substanceISORARB (Homo sapiens)6480464CTDRARB protein alternative form results in increased susceptibility to Tretinoin; RARB protein results in increased susceptibility to TretinoinPMID:16236281 PMID:16288117
Rarbmultiple interactionsISORarb (Rattus norvegicus)6480464CTD[Ethinyl Estradiol co-treated with Tretinoin] results in increased expression of RARB mRNA; Cycloheximide promotes the reaction [Tretinoin results in increased expression of RARB mRNA]; IL1B protein promotes the reaction [Tretinoin results in increased expression of RARB protein]; RARB mutant form inhibits the reaction [Tretinoin results in increased expression of SLC1A1 mRNA alternative form]; Tretinoin inhibits the reaction [Vitamin A affects the expression of RARB mRNA]; Tretinoin promotes the reaction [Cisplatin results in increased expression of RARB mRNA]; Tretinoin promotes the reaction [nitrofen results in increased expression of RARB mRNA]; Tretinoin promotes the reaction [Paclitaxel results in increased expression of RARB mRNA]PMID:11171635 PMID:16530976 PMID:17161848 PMID:19450544 PMID:21865574 PMID:26672737
Rarbmultiple interactionsISORARB (Homo sapiens)6480464CTD2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [Tretinoin results in increased expression of RARB mRNA]; 2-bromopalmitate promotes the reaction [Tretinoin results in increased expression of RARB mRNA]; [Decitabine co-treated with Tretinoin] results in increased expression of RARB mRNA; [Decitabine co-treated with trichostatin A co-treated with Tretinoin] affects the reaction [H3-4 protein modified form binds to RARB promoter]; [Tretinoin co-treated with Decitabine] results in increased expression of RARB mRNA; [Tretinoin co-treated with trichostatin A] results in increased expression of RARB mRNA; [Tretinoin co-treated with trichostatin A] results in increased expression of RARB protein; [Tretinoin co-treated with Vorinostat] results in increased expression of RARB mRNA alternative form; [trichostatin A co-treated with Tretinoin] results in increased expression of RARB protein; AGN 193109 inhibits the reaction [Tretinoin results in increased expression of RARB protein]; AKT1 protein inhibits the reaction [Tretinoin results in increased expression of RARB mRNA]; Arsenic Trioxide inhibits the reaction [Tretinoin results in increased expression of RARB mRNA]; Arsenic Trioxide inhibits the reaction [Tretinoin results in increased expression of RARB protein]; BMS453 inhibits the reaction [Tretinoin results in increased expression of RARB mRNA]; CD2665 inhibits the reaction [Tretinoin results in increased expression of RARB mRNA]; Decitabine promotes the reaction [Tretinoin results in increased expression of RARB mRNA]; Decitabine promotes the reaction [Tretinoin results in increased expression of RARB protein]; Quinolines analog inhibits the reaction [Tretinoin results in increased expression of RARB mRNA]; R116010 promotes the reaction [Tretinoin results in increased expression of RARB mRNA]; RARB protein promotes the reaction [Tretinoin results in increased expression of VEGFA mRNA]; SUMO1 mutant form inhibits the reaction [Tretinoin results in increased expression of RARB mRNA]; Tretinoin inhibits the reaction [RARB protein binds to FOLR2 promoter]; Tretinoin promotes the reaction [H4C16 protein modified form binds to RARB gene]; Tretinoin promotes the reaction [RARB protein alternative form binds to RBP1 promoter]; Tretinoin results in increased expression of and results in increased activity of RARB protein; trichostatin A promotes the reaction [Tretinoin results in increased expression of RARB protein]; TRIM16 protein promotes the reaction [Tretinoin results in increased expression of RARB mRNA]; triphenyl phosphate inhibits the reaction [Tretinoin results in increased expression of RARB mRNA]PMID:11133770 PMID:12839938 PMID:15959780 PMID:16158052 PMID:16184197 PMID:16289102 PMID:16417524 PMID:16636064 PMID:16740727 PMID:16832676 PMID:16894348 PMID:17077328 PMID:17079450 PMID:17170094 PMID:17486130 PMID:19524134 PMID:24819975 PMID:25725299 PMID:30076181 PMID:35483669
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