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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11204
Species: Mus musculus
RGD Object: Gene
Symbol: Slc39a7
Name: solute carrier family 39 (zinc transporter), member 7
Acc ID: CHEBI:30185
Term: zinc(0)
Definition: An elemental zinc that has formula Zn.
Chemical ID: MESH:D015032
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc39a7decreases expressionEXP 6480464CTDZinc results in decreased expression of SLC39A7 mRNAPMID:17085522
Slc39a7increases expressionEXP 6480464CTDZinc results in increased expression of SLC39A7 mRNAPMID:17085522
Slc39a7affects localizationISOSLC39A7 (Homo sapiens)6480464CTDSLC39A7 protein affects the localization of ZincPMID:15705588 PMID:18583420
Slc39a7decreases expressionISOSLC39A7 (Homo sapiens)6480464CTDZinc deficiency results in decreased expression of SLC39A7 mRNA; Zinc results in decreased expression of SLC39A7 mRNA; Zinc results in decreased expression of SLC39A7 proteinPMID:15705588 PMID:19071009 PMID:19720134
Slc39a7increases phosphorylationISOSLC39A7 (Homo sapiens)6480464CTDZinc results in increased phosphorylation of SLC39A7 proteinPMID:22317921
Slc39a7increases transportISOSLC39A7 (Homo sapiens)6480464CTDSLC39A7 protein results in increased transport of ZincPMID:18326752
Slc39a7multiple interactionsISOSLC39A7 (Homo sapiens)6480464CTD2-dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole inhibits the reaction [[Zinc co-treated with pyrithione] promotes the reaction [CSNK2A1 protein binds to SLC39A7 protein]]; 2-dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole inhibits the reaction [Zinc results in increased phosphorylation of SLC39A7 protein]; 4,5,6,7-tetrabromobenzotriazole inhibits the reaction [[Zinc co-treated with pyrithione] promotes the reaction [CSNK2A1 protein binds to SLC39A7 protein]]; [Zinc co-treated with pyrithione] promotes the reaction [CSNK2A1 protein binds to SLC39A7 protein]; SLC39A7 mutant form inhibits the reaction [Zinc results in increased phosphorylation of AKT1 protein]; Zinc promotes the reaction [CSNK2A1 protein binds to SLC39A7 protein]PMID:22317921
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