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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11184
Species: Mus musculus
RGD Object: Gene
Symbol: Ptgs1
Name: prostaglandin-endoperoxide synthase 1
Acc ID: CHEBI:31860
Term: Mofezolac (TN)
Definition: null
Chemical ID: MESH:C054999
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ptgs1decreases activityEXP 6480464CTDmofezolac results in decreased activity of PTGS1 proteinPMID:27050768
Ptgs1multiple interactionsEXP 6480464CTD[mofezolac results in decreased activity of PTGS1 protein] which results in decreased abundance of Dinoprostone; [mofezolac results in decreased activity of PTGS1 protein] which results in decreased expression of COL10A1 mRNA; [mofezolac results in decreased activity of PTGS1 protein] which results in decreased expression of COL10A1 protein; [mofezolac results in decreased activity of PTGS1 protein] which results in decreased expression of COL2A1 mRNA; [mofezolac results in decreased activity of PTGS1 protein] which results in decreased expression of COL2A1 protein; [mofezolac results in decreased activity of PTGS1 protein] which results in decreased expression of SOX9 mRNA; [mofezolac results in decreased activity of PTGS1 protein] which results in decreased expression of SOX9 proteinPMID:27050768
Ptgs1decreases activityISOPtgs1 (Rattus norvegicus)6480464CTDmofezolac results in decreased activity of PTGS1 proteinPMID:21510291
Ptgs1decreases expressionISOPtgs1 (Rattus norvegicus)6480464CTDmofezolac results in decreased expression of PTGS1PMID:21510291
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