GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Prnp | affects binding | EXP | | 6480464 | CTD | Copper binds to PRNP protein; PRNP protein binds to Copper | PMID:12500977 PMID:16595185 PMID:16698781 PMID:16787422 PMID:16990274 PMID:17112476 | Prnp | decreases response to substance | EXP | | 6480464 | CTD | PRNP protein results in decreased susceptibility to Copper | PMID:12500977 PMID:16787422 | Prnp | increases transport | EXP | | 6480464 | CTD | Copper results in increased transport of PRNP protein | PMID:21172064 | Prnp | increases uptake | EXP | | 6480464 | CTD | Copper results in increased uptake of PRNP protein | PMID:17155929 | Prnp | multiple interactions | EXP | | 6480464 | CTD | [[Hydrogen Peroxide co-treated with Copper] results in increased cleavage of PRNP protein] promotes the reaction [PRNP protein binds to PRNP protein]; [[PRNP protein binds to Copper] which co-treated with Hydrogen Peroxide] promotes the reaction [PRNP protein binds to PRNP protein]; [[PRNP protein binds to Copper] which co-treated with Hydrogen Peroxide] results in increased cleavage of [PRNP protein binds to PRNP protein]; [[PRNP protein binds to Copper] which co-treated with Hydrogen Peroxide] results in increased cleavage of PRNP protein; [ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of PRNP mRNA; [Copper co-treated with Filipin] results in increased cleavage of PRNP protein; [Hydrogen Peroxide co-treated with Copper] results in increased cleavage of PRNP protein; CAT protein inhibits the reaction [[[PRNP protein binds to Copper] which co-treated with Hydrogen Peroxide] results in increased cleavage of [PRNP protein binds to PRNP protein]]; CAT protein inhibits the reaction [[Hydrogen Peroxide co-treated with Copper] results in increased cleavage of PRNP protein]; Copper affects the localization of [GPC1 protein co-treated with PRNP protein]; Copper affects the reaction [LRP1 protein results in increased uptake of PRNP protein]; Copper promotes the reaction [PRNP protein binds to GRIN1 protein]; Edetic Acid inhibits the reaction [[Hydrogen Peroxide co-treated with Copper] results in increased cleavage of PRNP protein]; PRNP protein affects the reaction [Copper results in increased nitrosation of GPC1 protein] | PMID:15467011 PMID:16595185 PMID:16923158 PMID:17155929 PMID:18717736 PMID:19597535 PMID:22307640 | Prnp | affects binding | ISO | PRNP (Homo sapiens) | 6480464 | CTD | Copper binds to PRNP protein; PRNP protein binds to Copper; PRNP protein polymorphism binds to Copper | PMID:16824036 PMID:16831968 PMID:16847141 PMID:16990274 PMID:17112476 PMID:17126907 PMID:17257012 PMID:19236027 PMID:19697239 PMID:22791135 | Prnp | affects folding | ISO | PRNP (Homo sapiens) | 6480464 | CTD | Copper affects the folding of PRNP protein modified form | PMID:20936829 | Prnp | decreases response to substance | ISO | PRNP (Homo sapiens) | 6480464 | CTD | PRNP protein results in decreased susceptibility to Copper | PMID:21537833 | Prnp | increases cleavage | ISO | PRNP (Homo sapiens) | 6480464 | CTD | Copper results in increased cleavage of PRNP protein | PMID:19597535 | Prnp | increases expression | ISO | Prnp (Rattus norvegicus) | 6480464 | CTD | Copper deficiency results in increased expression of PRNP mRNA; Copper deficiency results in increased expression of PRNP protein; Copper results in increased expression of PRNP mRNA | PMID:22362149 PMID:22465980 | Prnp | increases reduction | ISO | PRNP (Homo sapiens) | 6480464 | CTD | PRNP protein results in increased reduction of Copper | PMID:12572668 | Prnp | increases uptake | ISO | Prnp (Rattus norvegicus) | 6480464 | CTD | PRNP protein results in increased uptake of Copper | PMID:19957168 PMID:22362149 | Prnp | multiple interactions | ISO | Prnp (Rattus norvegicus) | 6480464 | CTD | [PRNP protein results in increased uptake of Copper] which results in increased activity of SOD1 protein | PMID:22362149 | Prnp | multiple interactions | ISO | PRNP (Homo sapiens) | 6480464 | CTD | [[[Copper binds to PRNP protein] which results in increased reduction of Copper] which results in increased abundance of Reactive Oxygen Species] which results in increased cleavage of PRNP protein; [[Copper binds to PRNP protein] which results in increased reduction of Copper] which results in increased abundance of Reactive Oxygen Species; [Copper binds to PRNP protein] which results in increased reduction of Copper; [Copper co-treated with NADP] promotes the reaction [PRNP protein binds to PRNP protein]; [Copper co-treated with NADP] results in increased susceptibility to [PRNP protein binds to PRNP protein]; [PRNP protein binds to Copper] which results in increased activity of SOD1 protein; Copper affects the reaction [1,2-Dipalmitoylphosphatidylcholine affects the folding of PRNP protein modified form] | PMID:17112476 PMID:19149680 PMID:19697239 PMID:20936829 | | ||||||||||||||||||||||
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