Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11116
Species: Mus musculus
RGD Object: Gene
Symbol: Pla2g4a
Name: phospholipase A2, group IVA (cytosolic, calcium-dependent)
Acc ID: CHEBI:41879
Term: dexamethasone
Definition: A fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids.
Chemical ID: MESH:D003907
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pla2g4adecreases activityEXP 6480464CTDDexamethasone results in decreased activity of PLA2G4A proteinPMID:10874129
Pla2g4adecreases expressionEXP 6480464CTDDexamethasone results in decreased expression of PLA2G4A mRNA; Dexamethasone results in decreased expression of PLA2G4A proteinPMID:10874129
Pla2g4amultiple interactionsEXP 6480464CTDCycloheximide inhibits the reaction [Dexamethasone inhibits the reaction [Zymosan results in increased activity of PLA2G4A protein]]; Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of PLA2G4A mRNA]; Dexamethasone inhibits the reaction [Zymosan results in increased activity of PLA2G4A protein]PMID:10874129
Pla2g4amultiple interactionsISOPLA2G4A (Homo sapiens)6480464CTDDexamethasone inhibits the reaction [Histamine results in increased expression of PLA2G4A mRNA]; Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of PLA2G4A mRNA]PMID:20573295 PMID:9609743
Go Back to source page   Continue to Ontology report