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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11092
Species: Mus musculus
RGD Object: Gene
Symbol: Pgr
Name: progesterone receptor
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pgrdecreases activityISOPGR (Homo sapiens)6480464CTDresveratrol results in decreased activity of PGR proteinPMID:11507064
Pgrdecreases expressionISOPgr (Rattus norvegicus)6480464CTDresveratrol results in decreased expression of PGR mRNAPMID:11218048
Pgrdecreases expressionISOPGR (Homo sapiens)6480464CTDresveratrol results in decreased expression of PGR mRNA; resveratrol results in decreased expression of PGR proteinPMID:11606380 PMID:20706672
Pgrincreases expressionISOPgr (Rattus norvegicus)6480464CTDresveratrol results in increased expression of PGR proteinPMID:21248286
Pgrincreases expressionISOPGR (Homo sapiens)6480464CTDresveratrol metabolite results in increased expression of PGR mRNA; resveratrol results in increased expression of PGR mRNA; resveratrol results in increased expression of PGR proteinPMID:11606380 PMID:19496085 PMID:9391166
Pgrmultiple interactionsISOPGR (Homo sapiens)6480464CTD[resveratrol co-treated with pterostilbene] promotes the reaction [afimoxifene results in decreased expression of PGR mRNA]; [resveratrol co-treated with pterostilbene] promotes the reaction [Estradiol results in increased expression of PGR mRNA]; resveratrol inhibits the reaction [Estradiol results in increased expression of PGR mRNA]; resveratrol inhibits the reaction [Estradiol results in increased expression of PGR protein]; resveratrol inhibits the reaction [PGR protein affects the reaction [[Estradiol co-treated with Progesterone] results in increased expression of ITGA1]]PMID:11507064 PMID:11606380 PMID:11813992 PMID:27159275
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