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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11068
Species: Mus musculus
RGD Object: Gene
Symbol: Pdgfb
Name: platelet derived growth factor, B polypeptide
Acc ID: CHEBI:26523
Term: reactive oxygen species
Definition: Molecules or ions formed by the incomplete one-electron reduction of oxygen. They contribute to the microbicidal activity of phagocytes, regulation of signal transduction and gene expression, and the oxidative damage to biopolymers.
Chemical ID: MESH:D017382
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pdgfbincreases abundanceISOPdgfb (Rattus norvegicus)6480464CTDPDGFB protein results in increased abundance of Reactive Oxygen SpeciesPMID:21251946
Pdgfbincreases abundanceISOPDGFB (Homo sapiens)6480464CTDPDGFB protein results in increased abundance of Reactive Oxygen SpeciesPMID:11710721
Pdgfbmultiple interactionsISOPdgfb (Rattus norvegicus)6480464CTDdihydrolipoic acid affects the reaction [PDGFB protein results in increased abundance of Reactive Oxygen Species]PMID:21251946
Pdgfbmultiple interactionsISOPDGFB (Homo sapiens)6480464CTDcyanidin inhibits the reaction [[PDGFA protein co-treated with PDGFB protein] results in increased abundance of Reactive Oxygen Species]; delphinidin inhibits the reaction [[PDGFA protein co-treated with PDGFB protein] results in increased abundance of Reactive Oxygen Species]; malvidin inhibits the reaction [[PDGFA protein co-treated with PDGFB protein] results in increased abundance of Reactive Oxygen Species]; peonidin inhibits the reaction [[PDGFA protein co-treated with PDGFB protein] results in increased abundance of Reactive Oxygen Species]PMID:16921400
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