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GENE - TERM ANNOTATION REPORT

RGD ID: 11055
Species: Mus musculus
RGD Object: Gene
Symbol: Serpine1
Name: serine (or cysteine) peptidase inhibitor, clade E, member 1
Acc ID: DOID:11394
Term: adult respiratory distress syndrome
Definition: A respiratory failure that results from diffuse injury to the endothelium of the lung (as in sepsis, chest trauma, massive blood transfusion, aspiration of the gastric contents, or pneumonia) and is characterized by pulmonary edema with an abnormally high amount of protein in the edematous fluid and by difficult rapid breathing and hypoxemia. (DO)
Definition Source(s): http://www2.merriam-webster.com/cgi-bin/mwmednlm?book=Medical&va=adult+respiratory+distress+syndrome "DO" "DO", https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5392788/ "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Serpine1 ISOSERPINE1 (Homo sapiens)4144037RGDprotein:increased expression:plasma 
Serpine1 ISOSERPINE1 (Homo sapiens)4144039RGDassociated with Pneumonia, aspiration; protein:increased expression:Bronchoalveolar Lavage Fluid 
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