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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11055
Species: Mus musculus
RGD Object: Gene
Symbol: Serpine1
Name: serine (or cysteine) peptidase inhibitor, clade E, member 1
Acc ID: CHEBI:77149
Term: notoginsenoside R1
Definition: A ginsenoside found in Panax notoginseng that is dammarane which is substituted by hydroxy groups at the 3beta, 6alpha, 12beta and 20 pro-S positions, in which the hydroxy groups at positions 6 and 20 have been converted to the corresponding beta-D-xylopyranosyl-(1->2)-beta-D-glucopyranoside and beta-D-glucopyranoside respectively, and in which a double bond has been introduced at the 24-25 position.
Chemical ID: MESH:C072936
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Serpine1multiple interactionsEXP 6480464CTDnotoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of SERPINE1 protein]PMID:9102164
Serpine1decreases activityISOSERPINE1 (Homo sapiens)6480464CTDnotoginsenoside R1 results in decreased activity of SERPINE1 proteinPMID:8018658
Serpine1multiple interactionsISOSERPINE1 (Homo sapiens)6480464CTDnotoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of SERPINE1 mRNA]; notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of SERPINE1 protein]; notoginsenoside R1 inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of SERPINE1 protein]; notoginsenoside R1 inhibits the reaction [TNF protein results in increased expression of SERPINE1 mRNA]; notoginsenoside R1 results in increased expression of [PLAT protein binds to SERPINE1 protein]PMID:16458614 PMID:8018658 PMID:9102164
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