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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10996
Species: Mus musculus
RGD Object: Gene
Symbol: Nos2
Name: nitric oxide synthase 2, inducible
Acc ID: CHEBI:73755
Term: 1,2-dimethylhydrazine
Definition: A member of the class of hydrazines that is hydrazine in which one of the hydrogens attached to each nitrogen is replaced by a methyl group. A powerful DNA alkylating agent and carcinogen, it is used to induce colon cancer in laboratory rats and mice.
Chemical ID: MESH:D019813
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nos2increases expressionEXP 6480464CTD1,2-Dimethylhydrazine results in increased expression of NOS2 mRNAPMID:22982865
Nos2multiple interactionsEXP 6480464CTDCurcumin inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of NOS2 mRNA]PMID:22982865
Nos2increases expressionISONos2 (Rattus norvegicus)6480464CTD1,2-Dimethylhydrazine results in increased expression of NOS2 mRNA; 1,2-Dimethylhydrazine results in increased expression of NOS2 proteinPMID:18155637 PMID:30720227 PMID:31925992 PMID:35567572
Nos2multiple interactionsISONos2 (Rattus norvegicus)6480464CTDGallic Acid inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of NOS2 protein]; hesperetin inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of NOS2 protein]; Vanadium inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of NOS2 mRNA]; zingerone inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of NOS2 protein]PMID:18155637 PMID:30720227 PMID:31925992 PMID:35567572
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