GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Nos2 | affects response to substance | EXP | | 6480464 | CTD | NOS2 protein affects the susceptibility to Indomethacin | PMID:10964977 PMID:15138204 | Nos2 | decreases expression | EXP | | 6480464 | CTD | Indomethacin results in decreased expression of NOS2 protein | PMID:11292070 | Nos2 | increases expression | EXP | | 6480464 | CTD | Indomethacin results in increased expression of NOS2 mRNA | PMID:21691039 | Nos2 | multiple interactions | EXP | | 6480464 | CTD | 3-methylsydnone-5-nitrosimine inhibits the reaction [NOS2 gene mutant form results in decreased susceptibility to Indomethacin]; [Dexamethasone co-treated with Indomethacin] results in decreased expression of NOS2 protein; Domperidone inhibits the reaction [Indomethacin results in increased expression of NOS2 mRNA]; Indomethacin inhibits the reaction [[APP protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Indomethacin inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in increased expression of NOS2 mRNA]; Indomethacin inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in increased expression of NOS2 protein]; Indomethacin inhibits the reaction [Carrageenan results in increased expression of NOS2 protein]; Metoclopramide inhibits the reaction [Indomethacin results in increased expression of NOS2 mRNA] | PMID:10964977 PMID:11080519 PMID:18030227 PMID:21691039 PMID:22107987 PMID:26418808 | Nos2 | decreases expression | ISO | Nos2 (Rattus norvegicus) | 6480464 | CTD | Indomethacin results in decreased expression of NOS2 protein | PMID:15067210 | Nos2 | increases activity | ISO | Nos2 (Rattus norvegicus) | 6480464 | CTD | Indomethacin results in increased activity of NOS2 protein | PMID:10192188 PMID:10210152 PMID:10671773 PMID:11148446 PMID:11686837 PMID:11855677 PMID:11991626 PMID:12568917 PMID:15610444 PMID:16169175 PMID:16818512 PMID:16944022 | Nos2 | increases expression | ISO | Nos2 (Rattus norvegicus) | 6480464 | CTD | Indomethacin results in increased expression of NOS2 mRNA; Indomethacin results in increased expression of NOS2 protein | PMID:10210152 PMID:10574470 PMID:11145282 PMID:11713966 PMID:16133968 PMID:16944022 PMID:17202747 PMID:17657623 PMID:18306037 PMID:18996434 PMID:29027214 PMID:37483153 PMID:7529313 | Nos2 | increases expression | ISO | NOS2 (Homo sapiens) | 6480464 | CTD | Indomethacin results in increased expression of NOS2 mRNA | PMID:29027214 | Nos2 | multiple interactions | ISO | Nos2 (Rattus norvegicus) | 6480464 | CTD | 1-(4-chlorobenzoyl)-5-methoxy-2-1H-indole-3-acetic acid 3-(nitrooxymethyl)phenyl ester inhibits the reaction [Indomethacin results in increased activity of NOS2 protein]; 16,16-Dimethylprostaglandin E2 inhibits the reaction [Indomethacin results in increased activity of NOS2 protein]; 16,16-Dimethylprostaglandin E2 inhibits the reaction [Indomethacin results in increased expression of NOS2 mRNA]; [Indomethacin results in increased activity of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide; [morin co-treated with Indomethacin] inhibits the reaction [Freund's Adjuvant results in increased expression of NOS2 mRNA]; Ampicillin inhibits the reaction [Indomethacin results in increased activity of NOS2 protein]; Ampicillin inhibits the reaction [Indomethacin results in increased expression of NOS2 mRNA]; Arginine inhibits the reaction [Indomethacin results in increased expression of NOS2 mRNA]; Atropine inhibits the reaction [Indomethacin results in increased activity of NOS2 protein]; Atropine inhibits the reaction [Indomethacin results in increased expression of NOS2 mRNA]; Capsaicin inhibits the reaction [Indomethacin results in increased activity of NOS2 protein]; Dexamethasone inhibits the reaction [Indomethacin results in increased activity of NOS2 protein]; Dexamethasone inhibits the reaction [Indomethacin results in increased expression of NOS2 mRNA]; Dinoprostone inhibits the reaction [Indomethacin results in increased activity of NOS2 protein]; Dinoprostone inhibits the reaction [Indomethacin results in increased expression of NOS2 mRNA]; Indomethacin inhibits the reaction [Formaldehyde results in increased expression of NOS2 mRNA]; Indomethacin inhibits the reaction [Freund's Adjuvant results in increased expression of NOS2 mRNA]; irsogladine inhibits the reaction [Indomethacin results in increased expression of NOS2 mRNA]; lafutidine inhibits the reaction [Indomethacin results in increased activity of NOS2 protein]; Metronidazole inhibits the reaction [Indomethacin results in increased activity of NOS2 protein]; NG-Nitroarginine Methyl Ester inhibits the reaction [Arginine inhibits the reaction [Indomethacin results in increased expression of NOS2 mRNA]]; nitroaspirin inhibits the reaction [Indomethacin results in increased activity of NOS2 protein]; ONO-AE1-329 inhibits the reaction [Indomethacin results in increased activity of NOS2 protein]; ONO-NT 012 inhibits the reaction [Indomethacin results in increased activity of NOS2 protein]; Pentoxifylline inhibits the reaction [Indomethacin results in increased expression of NOS2 protein]; Polymyxin B inhibits the reaction [Indomethacin results in increased activity of NOS2 protein]; Ranitidine inhibits the reaction [Indomethacin results in increased activity of NOS2 protein]; rebamipide inhibits the reaction [Indomethacin results in increased activity of NOS2 protein]; sulglicotide inhibits the reaction [Indomethacin results in increased expression of NOS2 protein]; Tacrolimus inhibits the reaction [Indomethacin results in increased expression of NOS2 mRNA]; Theophylline inhibits the reaction [Indomethacin results in increased expression of NOS2 protein]; thiaton inhibits the reaction [Indomethacin results in increased activity of NOS2 protein]; TNF protein affects the reaction [Indomethacin results in increased expression of NOS2 protein]; usnic acid inhibits the reaction [Indomethacin results in increased activity of NOS2 protein] | PMID:10574470 PMID:10671773 PMID:11686837 PMID:11855677 PMID:11991626 PMID:12568917 PMID:15610444 PMID:16133968 PMID:16169175 PMID:16818512 PMID:16944022 PMID:17202747 PMID:17657623 PMID:18306037 PMID:21983654 PMID:25698669 PMID:37483153 | | ||||||||||||||||||||||
| Go Back to source page | Continue to Ontology report |