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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10996
Species: Mus musculus
RGD Object: Gene
Symbol: Nos2
Name: nitric oxide synthase 2, inducible
Acc ID: CHEBI:33191
Term: potassium cyanide
Definition: A cyanide salt containing equal numbers of potassium cations and cyanide anions.
Chemical ID: MESH:D011190
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nos2increases expressionISONos2 (Rattus norvegicus)6480464CTDPotassium Cyanide results in increased expression of NOS2 mRNA; Potassium Cyanide results in increased expression of NOS2 proteinPMID:16933320
Nos2multiple interactionsISONos2 (Rattus norvegicus)6480464CTDButhionine Sulfoximine promotes the reaction [Potassium Cyanide results in increased expression of NOS2 protein]; Ethacrynic Acid promotes the reaction [Potassium Cyanide results in increased expression of NOS2 protein]; N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [Potassium Cyanide results in increased expression of NOS2 protein]; S-ethyl glutathione inhibits the reaction [Potassium Cyanide results in increased expression of NOS2 protein]; SN50 peptide inhibits the reaction [Potassium Cyanide results in increased expression of NOS2 protein]PMID:16933320
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