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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10989
Species: Mus musculus
RGD Object: Gene
Symbol: Nog
Name: noggin
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nogincreases expressionISONOG (Homo sapiens)6480464CTDEstradiol results in increased expression of NOG mRNAPMID:21795739
Nogmultiple interactionsISONog (Rattus norvegicus)6480464CTDNOG protein promotes the reaction [GH1 protein inhibits the reaction [FSHB protein results in increased abundance of Estradiol]]PMID:22067323
Nogmultiple interactionsISONOG (Homo sapiens)6480464CTD[Estradiol co-treated with TGFB1 protein] results in increased expression of NOG mRNA; Estradiol promotes the reaction [ESR2 protein results in decreased expression of NOG mRNA]; Progesterone promotes the reaction [Estradiol results in increased expression of NOG mRNA]PMID:20404318 PMID:21795739 PMID:30165855
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