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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10975
Species: Mus musculus
RGD Object: Gene
Symbol: Nfkbia
Name: nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha
Acc ID: CHEBI:33146
Term: vanadyl sulfate
Definition: A vanadium coordination entity that has formula O5SV.
Chemical ID: MESH:C034028
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfkbiaincreases degradationISONFKBIA (Homo sapiens)6480464CTDvanadyl sulfate results in increased degradation of NFKBIA proteinPMID:10521501 PMID:10873158 PMID:11943669
Nfkbiaincreases phosphorylationISONFKBIA (Homo sapiens)6480464CTDvanadyl sulfate results in increased phosphorylation of NFKBIA proteinPMID:11943669
Nfkbiamultiple interactionsISONfkbia (Rattus norvegicus)6480464CTDvanadyl sulfate inhibits the reaction [Streptozocin results in increased expression of NFKBIA mRNA]PMID:16684804
Nfkbiamultiple interactionsISONFKBIA (Homo sapiens)6480464CTD4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [vanadyl sulfate results in increased degradation of NFKBIA protein]; CAT protein inhibits the reaction [vanadyl sulfate results in increased degradation of NFKBIA protein]; MRAS mutant form inhibits the reaction [vanadyl sulfate results in increased degradation of NFKBIA protein]; NFKBIA protein mutant form inhibits the reaction [vanadyl sulfate affects the localization of RELA protein]; NFKBIA protein mutant form inhibits the reaction [vanadyl sulfate results in increased expression of CXCL8 mRNA]PMID:10521501 PMID:10873158 PMID:11943669
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