GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Nfkbia | increases phosphorylation | EXP | | 6480464 | CTD | Copper analog results in increased phosphorylation of NFKBIA protein | PMID:21319953 | Nfkbia | multiple interactions | EXP | | 6480464 | CTD | [Disulfiram binds to Copper] which results in increased expression of NFKBIA protein | PMID:24690739 | Nfkbia | multiple interactions | ISO | Nfkbia (Rattus norvegicus) | 6480464 | CTD | [Copper co-treated with Diethylnitrosamine co-treated with Iron] results in decreased expression of NFKBIA mRNA; [Copper co-treated with Diethylnitrosamine] results in decreased expression of NFKBIA mRNA | PMID:20302851 | Nfkbia | multiple interactions | ISO | NFKBIA (Homo sapiens) | 6480464 | CTD | [Chelating Agents binds to Copper] which affects the expression of NFKBIA mRNA; [Chelating Agents binds to Copper] which results in decreased phosphorylation of NFKBIA protein; [Disulfiram binds to Copper] which results in increased expression of NFKBIA protein; Copper inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased degradation of NFKBIA protein] | PMID:18615482 PMID:24690739 PMID:30911355 | |
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