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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10975
Species: Mus musculus
RGD Object: Gene
Symbol: Nfkbia
Name: nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha
Acc ID: CHEBI:30052
Term: copper(0)
Definition: An elemental copper that has formula Cu.
Chemical ID: MESH:D003300
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfkbiaincreases phosphorylationEXP 6480464CTDCopper analog results in increased phosphorylation of NFKBIA proteinPMID:21319953
Nfkbiamultiple interactionsEXP 6480464CTD[Disulfiram binds to Copper] which results in increased expression of NFKBIA proteinPMID:24690739
Nfkbiamultiple interactionsISONfkbia (Rattus norvegicus)6480464CTD[Copper co-treated with Diethylnitrosamine co-treated with Iron] results in decreased expression of NFKBIA mRNA; [Copper co-treated with Diethylnitrosamine] results in decreased expression of NFKBIA mRNAPMID:20302851
Nfkbiamultiple interactionsISONFKBIA (Homo sapiens)6480464CTD[Chelating Agents binds to Copper] which affects the expression of NFKBIA mRNA; [Chelating Agents binds to Copper] which results in decreased phosphorylation of NFKBIA protein; [Disulfiram binds to Copper] which results in increased expression of NFKBIA protein; Copper inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased degradation of NFKBIA protein]PMID:18615482 PMID:24690739 PMID:30911355
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