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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10975
Species: Mus musculus
RGD Object: Gene
Symbol: Nfkbia
Name: nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha
Acc ID: CHEBI:29678
Term: sodium arsenite
Definition: An inoganic sodium salt with formula with formula NaAsO2.
Chemical ID: MESH:C017947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfkbiaaffects expressionEXP 6480464CTDsodium arsenite affects the expression of NFKBIA mRNAPMID:32194376
Nfkbiadecreases expressionEXP 6480464CTDsodium arsenite results in decreased expression of NFKBIA mRNAPMID:16014739 PMID:31233874
Nfkbiaincreases expressionEXP 6480464CTDsodium arsenite results in increased expression of NFKBIA; sodium arsenite results in increased expression of NFKBIA mRNAPMID:10896383 PMID:25367288
Nfkbiaincreases phosphorylationEXP 6480464CTDsodium arsenite results in increased phosphorylation of NFKBIA proteinPMID:29854073 PMID:34272803
Nfkbiamultiple interactionsEXP 6480464CTDCurcumin inhibits the reaction [sodium arsenite results in increased phosphorylation of NFKBIA protein]; salvin inhibits the reaction [sodium arsenite results in increased phosphorylation of NFKBIA protein]; sodium arsenite inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of NFKBIA protein]; sodium arsenite inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased degradation of NFKBIA protein]; sodium arsenite inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein]; sodium arsenite promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NFKBIA mRNA]; sodium arsenite promotes the reaction [Lipopolysaccharides results in increased expression of NFKBIA mRNA]PMID:10896383 PMID:12095131 PMID:16243048 PMID:23106696 PMID:29854073 PMID:34272803
Nfkbiaaffects expressionISONFKBIA (Homo sapiens)6480464CTDsodium arsenite affects the expression of NFKBIA mRNA; sodium arsenite affects the expression of NFKBIA proteinPMID:29528074 PMID:34032870
Nfkbiadecreases degradationISONFKBIA (Homo sapiens)6480464CTDsodium arsenite results in decreased degradation of NFKBIA proteinPMID:16497974
Nfkbiadecreases expressionISONfkbia (Rattus norvegicus)6480464CTDsodium arsenite results in decreased expression of NFKBIA proteinPMID:19429265
Nfkbiaincreases activityISONFKBIA (Homo sapiens)6480464CTDsodium arsenite results in increased activity of NFKBIA proteinPMID:23069812
Nfkbiaincreases degradationISONfkbia (Rattus norvegicus)6480464CTDsodium arsenite results in increased degradation of NFKBIA proteinPMID:15849723
Nfkbiaincreases expressionISONFKBIA (Homo sapiens)6480464CTDsodium arsenite results in increased expression of NFKBIA mRNA; sodium arsenite results in increased expression of NFKBIA protein modified formPMID:22714537 PMID:23219847
Nfkbiamultiple interactionsISONfkbia (Rattus norvegicus)6480464CTDsodium arsenite inhibits the reaction [Ceruletide results in increased degradation of NFKBIA protein]; Taurine inhibits the reaction [sodium arsenite results in decreased expression of NFKBIA protein]PMID:17941083 PMID:19429265
Nfkbiamultiple interactionsISONFKBIA (Homo sapiens)6480464CTD4(2'-aminoethyl)amino-1,8-dimethylimidazo(1,2-a)quinoxaline inhibits the reaction [sodium arsenite results in increased expression of NFKBIA protein modified form]; [sodium arsenite co-treated with Ethanol] results in decreased expression of NFKBIA protein; NFKBIA protein mutant form inhibits the reaction [sodium arsenite results in increased expression of CXCL8 mRNA]; sodium arsenite inhibits the reaction [[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with IL1B protein] results in increased expression of and results in increased phosphorylation of NFKBIA protein]; sodium arsenite inhibits the reaction [IL1B protein results in increased degradation of NFKBIA protein]; sodium arsenite inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; sodium arsenite results in decreased susceptibility to [TNF protein results in increased degradation of NFKBIA protein]; sodium arsenite results in increased phosphorylation of and results in increased degradation of NFKBIA proteinPMID:10521501 PMID:10799907 PMID:11835394 PMID:11835400 PMID:21761924 PMID:23219847 PMID:26220687
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