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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10975
Species: Mus musculus
RGD Object: Gene
Symbol: Nfkbia
Name: nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha
Acc ID: CHEBI:28757
Term: fructose
Definition: A ketohexose that is an isomer of glucose.
Chemical ID: MESH:D005632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfkbiadecreases expressionISONfkbia (Rattus norvegicus)6480464CTDFructose results in decreased expression of NFKBIA proteinPMID:31661889
Nfkbiaincreases degradationISONfkbia (Rattus norvegicus)6480464CTDFructose results in increased degradation of NFKBIA proteinPMID:26713546
Nfkbiaincreases phosphorylationISONfkbia (Rattus norvegicus)6480464CTDFructose results in increased phosphorylation of NFKBIA proteinPMID:24491314
Nfkbiamultiple interactionsISONfkbia (Rattus norvegicus)6480464CTDAllopurinol inhibits the reaction [Fructose results in increased phosphorylation of NFKBIA protein]; bisphenol A promotes the reaction [Fructose results in decreased expression of NFKBIA protein]; Curcumin inhibits the reaction [Fructose results in increased degradation of NFKBIA protein]; Fructose promotes the reaction [bisphenol A results in decreased expression of NFKBIA protein]; Quercetin inhibits the reaction [Fructose results in increased phosphorylation of NFKBIA protein]PMID:24491314 PMID:26713546 PMID:31661889
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