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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10940
Species: Mus musculus
RGD Object: Gene
Symbol: Myc
Name: myelocytomatosis oncogene
Acc ID: CHEBI:76290
Term: PhIP
Definition: An imidazopyridine that is 1H--imidazo[4,5-b]pyridine which is substituted at positions 1, 2, and 6 by methyl, amino, and phenyl groups, respectively. It is the most abundant of the mutagenic heterocyclic amines found in cooked meat and fish.
Chemical ID: MESH:C049584
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mycincreases expressionEXP 6480464CTD2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MYC proteinPMID:21081470
Mycincreases expressionISOMyc (Rattus norvegicus)6480464CTD2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MYC mRNAPMID:15059925
Mycincreases expressionISOMYC (Homo sapiens)6480464CTD2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MYC protein alternative formPMID:15319301
Mycmultiple interactionsISOMyc (Rattus norvegicus)6480464CTD[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dietary Fats] results in increased expression of MYC mRNA; [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dietary Fats] results in increased expression of MYC protein; [Dietary Fats co-treated with 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] results in increased expression of MYC mRNA; Caffeine promotes the reaction [[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dietary Fats] results in increased expression of MYC mRNA]; Plant Preparations promotes the reaction [[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dietary Fats] results in increased expression of MYC mRNA]PMID:18283038 PMID:18616682 PMID:8603490
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