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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10940
Species: Mus musculus
RGD Object: Gene
Symbol: Myc
Name: myelocytomatosis oncogene
Acc ID: CHEBI:52717
Term: bortezomib
Definition: L-Phenylalaninamide substituted at the amide nitrogen by a 1-(dihydroxyboranyl)-3-methylbutyl group and at N(alpha) by a pyrazin-2-ylcarbonyl group. It is a dipeptidyl boronic acid that reversibly inhibits the 26S proteasome.
Chemical ID: MESH:D000069286
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mycdecreases expressionISOMYC (Homo sapiens)6480464CTDBortezomib results in decreased expression of MYC proteinPMID:19417023 PMID:20022965
Mycincreases expressionISOMYC (Homo sapiens)6480464CTDBortezomib results in increased expression of MYC proteinPMID:12902978
Mycmultiple interactionsISOMYC (Homo sapiens)6480464CTD[Bortezomib co-treated with abexinostat] results in decreased expression of MYC mRNA; Bortezomib promotes the reaction [abexinostat results in decreased expression of MYC protein]; MYC protein promotes the reaction [Bortezomib results in increased expression of HSPA5 protein]; MYC protein promotes the reaction [Bortezomib results in increased expression of PMAIP1 protein]PMID:18641367 PMID:19417023
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