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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10940
Species: Mus musculus
RGD Object: Gene
Symbol: Myc
Name: myelocytomatosis oncogene
Acc ID: CHEBI:35255
Term: chloroform
Definition: A one-carbon compound that is methane in which three of the hydrogens are replaced by chlorines.
Chemical ID: MESH:D002725
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mycdecreases methylationEXP 6480464CTDChloroform results in decreased methylation of MYC promoterPMID:11099637 PMID:16014735
Mycincreases expressionEXP 6480464CTDChloroform results in increased expression of MYC mRNAPMID:11532874 PMID:8625290
Mycmultiple interactionsEXP 6480464CTDChloroform inhibits the reaction [Dichloroacetic Acid results in decreased expression of MYC mRNA]; Chloroform inhibits the reaction [Dichloroacetic Acid results in decreased methylation of MYC gene]; Chloroform inhibits the reaction [Dichloroacetic Acid results in increased expression of MYC mRNA]; Chloroform promotes the reaction [Dichloroacetic Acid results in decreased methylation of MYC promoter]PMID:11532874 PMID:16014735
Mycincreases expressionISOMyc (Rattus norvegicus)6480464CTDChloroform results in increased expression of MYC mRNAPMID:8625290
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