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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10916
Species: Mus musculus
RGD Object: Gene
Symbol: Mpo
Name: myeloperoxidase
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mpodecreases activityEXP 6480464CTDresveratrol analog results in decreased activity of MPO proteinPMID:19066340
Mpoincreases activityEXP 6480464CTDresveratrol results in increased activity of MPO proteinPMID:19066340 PMID:20067468
Mpomultiple interactionsEXP 6480464CTD[Resveratrol co-treated with Tetracyclines] inhibits the reaction [Paraquat results in increased activity of MPO protein]; Resveratrol affects the reaction [MPO protein affects the susceptibility to Rotenone]; Resveratrol inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of MPO protein]; Resveratrol inhibits the reaction [Dextran Sulfate results in increased activity of MPO protein]; Resveratrol inhibits the reaction [Rotenone results in increased expression of MPO protein]; Resveratrol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MPO]PMID:10381133 PMID:20637373 PMID:23593274 PMID:28090784
Mpodecreases activityISOMpo (Rattus norvegicus)6480464CTDresveratrol results in decreased activity of MPO proteinPMID:15637762 PMID:16971220 PMID:20117814 PMID:21192278 PMID:23593274
Mpodecreases expressionISOMpo (Rattus norvegicus)6480464CTDresveratrol results in decreased expression of MPO; resveratrol results in decreased expression of MPO proteinPMID:16488442 PMID:18277952 PMID:21111721 PMID:23371441 PMID:23593274 PMID:23612842
Mpomultiple interactionsISOMPO (Homo sapiens)6480464CTDresveratrol inhibits the reaction [MPO protein results in increased expression of NOS2 mRNA]; resveratrol inhibits the reaction [MPO protein results in increased expression of PTGS2 mRNA]; resveratrol inhibits the reaction [MPO protein results in increased expression of TNF mRNA]PMID:23593274
Mpomultiple interactionsISOMpo (Rattus norvegicus)6480464CTDchromium mesoporphyrin inhibits the reaction [resveratrol results in decreased activity of MPO protein]; fulvestrant inhibits the reaction [resveratrol results in decreased activity of MPO protein]; fulvestrant inhibits the reaction [resveratrol results in decreased expression of MPO protein]; HMOX1 protein promotes the reaction [resveratrol results in decreased activity of MPO protein]; resveratrol inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of MPO protein]; resveratrol inhibits the reaction [Bleomycin results in increased activity of MPO protein]; resveratrol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of MPO protein]; resveratrol inhibits the reaction [Methotrexate results in increased expression of MPO]; resveratrol inhibits the reaction [Oxazolone results in increased activity of MPO protein]; resveratrol inhibits the reaction [Rotenone results in increased expression of MPO protein]; resveratrol inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein]; SB 203580 inhibits the reaction [resveratrol results in decreased activity of MPO protein]; wortmannin inhibits the reaction [resveratrol results in decreased activity of MPO protein]PMID:15734790 PMID:16474422 PMID:17035056 PMID:18277952 PMID:20117814 PMID:21192278 PMID:22029500 PMID:23593274 PMID:24055189 PMID:25418378 PMID:26517535
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