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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10900
Species: Mus musculus
RGD Object: Gene
Symbol: Kmt2a
Name: lysine (K)-specific methyltransferase 2A
Acc ID: CHEBI:567361
Term: cladribine
Definition: 2'-Deoxyadenosine in which the hydrogen at position 2 on the purine ring has been substituted by chlorine. It inhibits the synthesis and repair of DNA, particularly in lymphocytes and monocytes, and is used as an antimetabolite antineoplastic drug for the treatment of lymphoid malignancies including hairy-cell leukaemia and chronic lymphocytic leukaemia.
Chemical ID: MESH:D017338
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Kmt2aincreases response to substanceISOKMT2A (Homo sapiens)6480464CTDKMT2A gene mutant form results in increased susceptibility to CladribinePMID:14712291
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