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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10876
Species: Mus musculus
RGD Object: Gene
Symbol: Lpl
Name: lipoprotein lipase
Acc ID: CHEBI:34372
Term: 4,4'-sulfonyldiphenol
Definition: A sulfone that is diphenyl sulfone in which both of the para hydrogens have been replaced by hydroxy groups.
Chemical ID: MESH:C543008
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Lplincreases expressionEXP 6480464CTDbisphenol S results in increased expression of LPL mRNAPMID:30951980
Lplmultiple interactionsEXP 6480464CTD2-chloro-5-nitrobenzanilide inhibits the reaction [[bisphenol S co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of LPL mRNA]; 2-chloro-5-nitrobenzanilide inhibits the reaction [[bisphenol S co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of LPL protein]; [bisphenol S co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of LPL mRNA; [bisphenol S co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of LPL proteinPMID:27273607
Lplincreases expressionISOLPL (Homo sapiens)6480464CTDbisphenol S results in increased expression of LPL mRNA; bisphenol S results in increased expression of LPL proteinPMID:27003841 PMID:27685785 PMID:34186270 PMID:36565802
Lplmultiple interactionsISOLPL (Homo sapiens)6480464CTD[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of LPL mRNA; [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of LPL protein; [bisphenol S co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in decreased expression of LPL protein; [bisphenol S co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of LPL mRNAPMID:33865937 PMID:35736896
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