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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10876
Species: Mus musculus
RGD Object: Gene
Symbol: Lpl
Name: lipoprotein lipase
Acc ID: CHEBI:32509
Term: pirinixic acid
Definition: An aryl sulfide that has formula C14H14ClN3O2S.
Chemical ID: MESH:C006253
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Lplaffects expressionEXP 6480464CTDpirinixic acid affects the expression of LPL mRNAPMID:19136022
Lpldecreases expressionEXP 6480464CTDpirinixic acid results in decreased expression of LPL mRNAPMID:18445702
Lplincreases expressionEXP 6480464CTDpirinixic acid results in increased expression of LPL mRNAPMID:11798191 PMID:15375163 PMID:16221962 PMID:16306350 PMID:16357043 PMID:17690133 PMID:17950772 PMID:18301758 PMID:20059764 PMID:20813756 PMID:23811191 PMID:28049043
Lplmultiple interactionsEXP 6480464CTDPPARA gene mutant form inhibits the reaction [pirinixic acid results in increased expression of LPL mRNA]; PPARA protein affects the reaction [pirinixic acid results in increased expression of LPL mRNA]; PPARA protein promotes the reaction [pirinixic acid results in increased expression of LPL mRNA]PMID:16221962 PMID:17950772 PMID:20059764 PMID:28049043
Lplincreases expressionISOLpl (Rattus norvegicus)6480464CTDpirinixic acid results in increased expression of LPL mRNAPMID:19162173
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