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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10876
Species: Mus musculus
RGD Object: Gene
Symbol: Lpl
Name: lipoprotein lipase
Acc ID: CHEBI:31638
Term: fulvestrant
Definition: A 3-hydroxy steroid that is 17beta-estradiol in which the 7alpha hydrogen has been replaced by a nonyl group in which one of the hydrogens of the terminal methyl has been replaced by a (4,4,5,5,5-pentafluoropentyl)sulfinyl group. An estrogen receptor antagonist, it is used in the treatment of breast cancer.
Chemical ID: MESH:C070081
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Lpldecreases expressionEXP 6480464CTDfulvestrant results in decreased expression of LPL mRNAPMID:17974624
Lplmultiple interactionsEXP 6480464CTDFulvestrant inhibits the reaction [bisphenol A glucuronide results in increased expression of LPL protein]; Fulvestrant inhibits the reaction [Diazinon results in increased expression of LPL mRNA]; Fulvestrant inhibits the reaction [ESR1 protein promotes the reaction [Estradiol results in increased expression of LPL mRNA]]; Fulvestrant inhibits the reaction [ESR2 protein promotes the reaction [Estradiol results in increased expression of LPL mRNA]]; Fulvestrant inhibits the reaction [Estradiol results in increased expression of LPL mRNA]; Fulvestrant inhibits the reaction [phoxim results in increased expression of LPL mRNA]; Fulvestrant inhibits the reaction [terbufos results in increased expression of LPL mRNA]; Fulvestrant inhibits the reaction [tolclofos-methyl results in increased expression of LPL mRNA]PMID:17974624 PMID:26018136 PMID:33872936
Lpldecreases expressionISOLPL (Homo sapiens)6480464CTDFulvestrant results in decreased expression of LPL mRNAPMID:31646340
Lplmultiple interactionsISOLPL (Homo sapiens)6480464CTD[bisphenol A co-treated with Fulvestrant] affects the methylation of LPL genePMID:31601247
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