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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10869
Species: Mus musculus
RGD Object: Gene
Symbol: Lhb
Name: luteinizing hormone beta
Acc ID: CHEBI:4903
Term: 17alpha-ethynylestradiol
Definition: A 3-hydroxy steroid that is estradiol substituted by a ethynyl group at position 17. It is a xenoestrogen synthesized from estradiol and has been shown to exhibit high estrogenic potency on oral administration.
Chemical ID: MESH:D004997
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Lhbdecreases activityISOLHB (Homo sapiens)6480464CTDEthinyl Estradiol results in decreased activity of LHB proteinPMID:31212720
Lhbdecreases expressionISOLhb (Rattus norvegicus)6480464CTDEthinyl Estradiol results in decreased expression of LHBPMID:25615539
Lhbdecreases expressionISOLHB (Homo sapiens)6480464CTDEthinyl Estradiol results in decreased expression of LHB proteinPMID:10843175 PMID:11907703
Lhbincreases secretionISOLhb (Rattus norvegicus)6480464CTDEthinyl Estradiol results in increased secretion of LHB proteinPMID:28522409
Lhbmultiple interactionsISOLHB (Homo sapiens)6480464CTD[Ethinyl Estradiol co-treated with Cyproterone Acetate] results in decreased expression of LHB protein; [Ethinyl Estradiol co-treated with Desogestrel] results in decreased expression of LHB protein; [Ethinyl Estradiol co-treated with Levonorgestrel] results in decreased expression of LHB protein; Avosentan affects the reaction [[Ethinyl Estradiol co-treated with Levonorgestrel] affects the expression of LHB protein]; Simvastatin promotes the reaction [[Ethinyl Estradiol co-treated with Desogestrel] results in decreased expression of LHB protein]PMID:16002536 PMID:16291413 PMID:17105841 PMID:17190377
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