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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10869
Species: Mus musculus
RGD Object: Gene
Symbol: Lhb
Name: luteinizing hormone beta
Acc ID: CHEBI:16581
Term: pregnenolone
Definition: A 20-oxo steroid that is pregn-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 20.
Chemical ID: MESH:D011284
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Lhbincreases abundanceISOLhb (Rattus norvegicus)6480464CTDLHB protein results in increased abundance of PregnenolonePMID:6430271
Lhbmultiple interactionsISOLhb (Rattus norvegicus)6480464CTD4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine inhibits the reaction [LHB protein results in increased abundance of Pregnenolone]; 5,8,11,14-Eicosatetraynoic Acid inhibits the reaction [LHB protein results in increased abundance of Pregnenolone]; benoxaprofen inhibits the reaction [LHB protein results in increased abundance of Pregnenolone]; Masoprocol inhibits the reaction [LHB protein results in increased abundance of Pregnenolone]PMID:6430271
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