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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10828
Species: Mus musculus
RGD Object: Gene
Symbol: Jun
Name: jun proto-oncogene
Acc ID: CHEBI:6809
Term: methamphetamine
Definition: A member of the class of amphetamines in which the amino group of (S)-amphetamine carries a methyl substituent.
Chemical ID: MESH:D008694
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Junaffects response to substanceEXP 6480464CTDJUN protein affects the susceptibility to MethamphetaminePMID:12391261
Junincreases expressionEXP 6480464CTDMethamphetamine results in increased expression of JUN proteinPMID:12391261
Junmultiple interactionsEXP 6480464CTDJUN protein affects the reaction [Methamphetamine results in increased activity of CASP3 protein]PMID:12391261
Junincreases activityISOJUN (Homo sapiens)6480464CTDMethamphetamine results in increased activity of JUN proteinPMID:11746378
Junincreases expressionISOJun (Rattus norvegicus)6480464CTDMethamphetamine results in increased expression of JUN mRNAPMID:10336889 PMID:15644446 PMID:19564919
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