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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10828
Species: Mus musculus
RGD Object: Gene
Symbol: Jun
Name: jun proto-oncogene
Acc ID: CHEBI:52497
Term: maneb
Definition: A polymeric complex of manganese with the ethylene bis(dithiocarbamate) anionic ligand. An agrochemical fungicide, it is used to control a variety of diseases including blight, leaf spot, rust, downy mildew and scab.
Chemical ID: MESH:D008344
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Junmultiple interactionsISOJun (Rattus norvegicus)6480464CTD[Paraquat co-treated with Maneb] results in decreased expression of JUN mRNA; [Paraquat co-treated with Maneb] results in decreased expression of JUN protein; Taurine inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of JUN mRNA]; Taurine inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of JUN protein]PMID:27460631 PMID:33368748
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