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GENE - TERM ANNOTATION REPORT

RGD ID: 10823
Species: Mus musculus
RGD Object: Gene
Symbol: Jak2
Name: Janus kinase 2
Acc ID: DOID:8432
Term: polycythemia
Definition: A bone marrow disease characterized by an increased number of red blood cells in the bloodstream resulting in thicker blood and reduced blood flow. (DO)
Definition Source(s): https://rarediseases.info.nih.gov/diseases/7422/polycythemia-vera "DO" "DO", https://www.nhlbi.nih.gov/health-topics/polycythemia-vera "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Jak2 IMP 10449378RGD  
Jak2 IMP 10449392RGD  
Jak2 ISOJAK2 (Homo sapiens)11554173CTDCTD Direct Evidence: marker/mechanismPMID:17267906
Jak2 ISOJAK2 (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: ERYTHROCYTOSIS, SOMATICPMID:15781101 PMID:15793561 PMID:15837627 PMID:15858187 PMID:15920007 PMID:16081687 PMID:16247455 PMID:16293597 PMID:16325696 PMID:16603627 PMID:16707754 PMID:16709929 PMID:16762626 PMID:17989398 PMID:18256599 PMID:18394554 PMID:19036091 PMID:19074595 PMID:19287384 PMID:19293426 PMID:20339092 PMID:20631743 PMID:20703299 PMID:21120162 PMID:21689158 PMID:22041374 PMID:22397670 PMID:22422826 PMID:22571758 PMID:22818858 PMID:22829971 PMID:23115274 PMID:23535062 PMID:24404189 PMID:24728327 PMID:24986690 PMID:25043017 PMID:25157968 PMID:25671252 PMID:25741868 PMID:28492532 PMID:32581362
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