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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10823
Species: Mus musculus
RGD Object: Gene
Symbol: Jak2
Name: Janus kinase 2
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Jak2decreases phosphorylationEXP 6480464CTDQuercetin results in decreased phosphorylation of JAK2 proteinPMID:24275163
Jak2decreases expressionISOJak2 (Rattus norvegicus)6480464CTDQuercetin analog results in decreased expression of JAK2 proteinPMID:23907460
Jak2decreases phosphorylationISOJAK2 (Homo sapiens)6480464CTDQuercetin results in decreased phosphorylation of JAK2 proteinPMID:24275163
Jak2increases expressionISOJAK2 (Homo sapiens)6480464CTDQuercetin results in increased expression of JAK2 mRNAPMID:21632981
Jak2increases phosphorylationISOJak2 (Rattus norvegicus)6480464CTDQuercetin analog results in increased phosphorylation of JAK2 proteinPMID:23907460
Jak2multiple interactionsISOJak2 (Rattus norvegicus)6480464CTDalpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide promotes the reaction [Quercetin analog results in decreased expression of JAK2 protein]; Quercetin inhibits the reaction [cypermethrin results in increased expression of JAK2 mRNA]; Quercetin inhibits the reaction [Fructose results in decreased phosphorylation of JAK2 protein]PMID:22426011 PMID:23907460 PMID:35876585
Jak2multiple interactionsISOJAK2 (Homo sapiens)6480464CTD[Quercetin analog co-treated with Gold analog] results in decreased phosphorylation of JAK2 proteinPMID:27470402
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