GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Ins2 | decreases expression | ISO | INS (Homo sapiens) | 6480464 | CTD | Glyburide results in decreased expression of INS protein | PMID:15642492 | Ins2 | increases expression | ISO | INS (Homo sapiens) | 6480464 | CTD | Glyburide results in increased expression of INS mRNA | PMID:15642492 | Ins2 | increases response to substance | ISO | Ins2 (Rattus norvegicus) | 6480464 | CTD | Glyburide results in increased susceptibility to INS protein | PMID:3116364 | Ins2 | increases secretion | ISO | INS (Homo sapiens) | 6480464 | CTD | Glyburide results in increased secretion of INS protein | PMID:10430617 | Ins2 | multiple interactions | ISO | INS (Homo sapiens) | 6480464 | CTD | [Glyburide co-treated with Glucose] results in increased expression of INS protein; Glyburide inhibits the reaction [Glucose results in decreased secretion of INS protein]; IRS1 protein polymorphism inhibits the reaction [Glyburide results in increased secretion of INS protein] | PMID:10430617 PMID:11305519 PMID:15642492 | | ||||||||||||||||||||||
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