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GENE - TERM ANNOTATION REPORT

RGD ID: 10802
Species: Mus musculus
RGD Object: Gene
Symbol: Il6
Name: interleukin 6
Acc ID: DOID:9000998
Term: Brain Injuries
Definition: Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.
Definition Source(s): MESH:D001930
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il6 ISOIl6 (Rattus norvegicus)11049549RGDprotein:increased expression:cerebrospinal fluid (rat) 
Il6 ISOIL6 (Homo sapiens)11554173CTDCTD Direct Evidence: marker/mechanismPMID:19800810 PMID:21549006 PMID:23159883
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