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GENE - TERM ANNOTATION REPORT

RGD ID: 10802
Species: Mus musculus
RGD Object: Gene
Symbol: Il6
Name: interleukin 6
Acc ID: DOID:1596
Term: depressive disorder
Definition: A mood disorder characterized by persistent sadness, emptiness, or irritability and decreased ability to function. (DO)
Definition Source(s): https://my.clevelandclinic.org/health/diseases/9290-depression "DO" "DO", https://pubmed.ncbi.nlm.nih.gov/31550874/ "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il6 IEP 126908003RGDprotein:increased expression:serum, hippocampus (mouse) 
Il6 ISOIL6 (Homo sapiens)38676480RGDassociated with Chronic Hepatitis C; DNA:insertion/deletion:promoter: 
Il6 ISOIL6 (Homo sapiens)126908003RGDassociated with gastric adenocarcinoma; protein:increased expression:blood serum (human) 
Il6 ISOIl6 (Rattus norvegicus)10402829RGDmRNA:increased expression:colon 
Il6 ISOIl6 (Rattus norvegicus)11062144RGDprotein:increased expression:hippocampus (rat) 
Il6treatmentISOIL6 (Homo sapiens)14975286RGDassociated with Hepatitis C, Chronic;DNA:SNP:promoter:-174G>C (human) 
Il6 ISOIL6 (Homo sapiens)11554173CTDCTD Direct Evidence: marker/mechanismPMID:18458677
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