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GENE - TERM ANNOTATION REPORT

RGD ID: 10802
Species: Mus musculus
RGD Object: Gene
Symbol: Il6
Name: interleukin 6
Acc ID: DOID:0080600
Term: COVID-19
Definition: A Coronavirus infectious disease that is characterized by fever, cough and shortness of breath and that has_material_basis_in SARS-CoV-2. (DO)
Definition Source(s): https://www.cdc.gov/coronavirus/2019-ncov/about/index.html "DO" "DO", https://www.ncbi.nlm.nih.gov/pubmed/?term=32007143 "DO" "DO", https://www.ncbi.nlm.nih.gov/pubmed/?term=32007145 "DO" "DO", https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=2697049 "DO" "DO", https://www.who.int/emergencies/diseases/novel-coronavirus-2019 "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il6 ISOIL6 (Homo sapiens)30296676RGDprotein:increased expression:serum: 
Il6 ISOIL6 (Homo sapiens)38501088RGDprotein:increased expression:plasma (human) 
Il6disease_progressionISOIL6 (Homo sapiens)30296681RGDassociated with diabetes mellitus 
Il6disease_progressionISOIL6 (Homo sapiens)30309206RGD  
Il6severityISOIL6 (Homo sapiens)27095965RGDprotein:increased expression:serum (human) 
Il6severityISOIL6 (Homo sapiens)27226695RGDprotein:increased expression:serum (human) 
Il6severityISOIL6 (Homo sapiens)30309200RGDprotein:increased expression:serum (human) 
Il6severityISOIL6 (Homo sapiens)30309212RGDprotein:increased expression:plasma (human) 
Il6severityISOIL6 (Homo sapiens)30309957RGDassociated with cardiovascular system disease;protein:increased expression:blood (human) 
Il6severityISOIL6 (Homo sapiens)30310229RGDprotein:increased expression:serum (human) 
Il6severityISOIL6 (Homo sapiens)30310230RGDprotein:increased expression:blood (human) 
Il6severityISOIL6 (Homo sapiens)30310238RGDprotein:increased expression:serum (human) 
Il6severityISOIL6 (Homo sapiens)32716368RGDprotein:increased expression:serum (human) 
Il6severityISOIL6 (Homo sapiens)36049814RGDprotein:increased expression:serum (human) 
Il6 ISOIL6 (Homo sapiens)11554173CTDCTD Direct Evidence: marker/mechanismPMID:32026671 PMID:32161940 PMID:32171193 PMID:32534021
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