GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Il6 | multiple interactions | EXP | | 6480464 | CTD | [Chloroquine co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL6 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Chloroquine co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL6 protein]; Bortezomib inhibits the reaction [[Chloroquine co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL6 protein]; Chloroquine inhibits the reaction [CPG-oligonucleotide results in increased secretion of IL6 protein]; Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 mRNA]; Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of IL6 protein]; Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL6 protein]; Chloroquine inhibits the reaction [Resveratrol inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of IL6 protein]]; Chloroquine promotes the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of IL6 mRNA]; Chloroquine promotes the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of IL6 protein]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 mRNA]]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of IL6 protein]] | PMID:22341560 PMID:26498332 PMID:28134560 PMID:9799232 | Il6 | decreases expression | ISO | IL6 (Homo sapiens) | 6480464 | CTD | Chloroquine results in decreased expression of IL6 protein | PMID:10638776 | Il6 | decreases secretion | ISO | IL6 (Homo sapiens) | 6480464 | CTD | Chloroquine results in decreased secretion of IL6 protein | PMID:29772762 | Il6 | increases expression | ISO | IL6 (Homo sapiens) | 6480464 | CTD | Chloroquine results in increased expression of IL6 | PMID:15139008 | Il6 | multiple interactions | ISO | IL6 (Homo sapiens) | 6480464 | CTD | Chloroquine inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; Chloroquine inhibits the reaction [Rifampin inhibits the reaction [Rotenone results in increased expression of IL6 mRNA]] | PMID:31648047 PMID:9002011 | Il6 | multiple interactions | ISO | Il6 (Rattus norvegicus) | 6480464 | CTD | Chloroquine inhibits the reaction [3,4-dihydroxyphenylethanol inhibits the reaction [Hydrogen Peroxide results in increased secretion of IL6 protein]] | PMID:31332898 | | ||||||||||||||||||||||
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