Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10802
Species: Mus musculus
RGD Object: Gene
Symbol: Il6
Name: interleukin 6
Acc ID: CHEBI:33217
Term: 3,3',5,5'-tetrabromobisphenol A
Definition: A bromobisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups and the phenyl rings are substituted by bromo groups at positions 2, 2', 6 and 6'. It is a brominated flame retardant.
Chemical ID: MESH:C020806
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il6increases expressionEXP 6480464CTDtetrabromobisphenol A results in increased expression of IL6 mRNAPMID:20077215 PMID:27592553
Il6increases secretionEXP 6480464CTDtetrabromobisphenol A results in increased secretion of IL6 proteinPMID:20077215 PMID:27592553
Il6increases expressionISOIL6 (Homo sapiens)6480464CTDtetrabromobisphenol A results in increased expression of IL6 mRNA; tetrabromobisphenol A results in increased expression of IL6 proteinPMID:25461914 PMID:26718265 PMID:30055667
Il6increases secretionISOIL6 (Homo sapiens)6480464CTDtetrabromobisphenol A results in increased secretion of IL6 proteinPMID:25461914
Il6increases secretionISOIl6 (Rattus norvegicus)6480464CTDtetrabromobisphenol A results in increased secretion of IL6 proteinPMID:31332466
Il6multiple interactionsISOIL6 (Homo sapiens)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [tetrabromobisphenol A results in increased expression of IL6 protein]; RTKI cpd inhibits the reaction [tetrabromobisphenol A results in increased expression of IL6 protein]; SB 203580 inhibits the reaction [tetrabromobisphenol A results in increased expression of IL6 protein]PMID:26718265
Il6multiple interactionsISOIl6 (Rattus norvegicus)6480464CTD[N-acetylglucosaminono-1,5-lactone O-(phenylcarbamoyl)oxime co-treated with tetrabromobisphenol A] results in increased secretion of IL6 proteinPMID:31332466
Go Back to source page   Continue to Ontology report