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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10802
Species: Mus musculus
RGD Object: Gene
Symbol: Il6
Name: interleukin 6
Acc ID: CHEBI:28694
Term: copper atom
Definition: A copper group element atom that has formula Cu.
Chemical ID: MESH:D003300
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il6multiple interactionsEXP 6480464CTDCopper promotes the reaction [APP protein modified form results in increased expression of and results in increased secretion of IL6 protein]PMID:27122238
Il6decreases secretionISOIL6 (Homo sapiens)6480464CTDCopper results in decreased secretion of IL6 proteinPMID:2107032
Il6multiple interactionsISOIL6 (Homo sapiens)6480464CTD[Chelating Agents binds to Copper] which results in decreased expression of IL6 mRNA; [diglycyl-histidine co-treated with Copper] inhibits the reaction [TNF protein results in increased secretion of IL6 protein]; [Disulfiram binds to Copper] which results in increased expression of IL6 mRNA; [Zinc co-treated with Copper co-treated with Aluminum] results in increased expression of IL6 proteinPMID:23285694 PMID:24690739 PMID:27816692 PMID:30911355
Il6multiple interactionsISOIl6 (Rattus norvegicus)6480464CTD[Copper Sulfate results in increased abundance of Copper] which results in increased expression of IL6 protein; [gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of IL6 mRNA; [Iron co-treated with Diethylnitrosamine co-treated with Copper] results in decreased expression of IL6 mRNA; Curcumin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in increased expression of IL6 protein]; Deferoxamine inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in increased expression of IL6 protein]PMID:20302851 PMID:25813056 PMID:34577062
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