GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Il6 | affects expression | EXP | | 6480464 | CTD | Tetrachlorodibenzodioxin affects the expression of IL6 mRNA | PMID:12167310 PMID:21570461 | Il6 | decreases expression | EXP | | 6480464 | CTD | Tetrachlorodibenzodioxin results in decreased expression of IL6 mRNA; Tetrachlorodibenzodioxin results in decreased expression of IL6 protein | PMID:18691609 PMID:21131560 PMID:32553695 PMID:9224809 | Il6 | increases expression | EXP | | 6480464 | CTD | Tetrachlorodibenzodioxin results in increased expression of IL6 mRNA | PMID:22430074 PMID:22564538 PMID:26862745 | Il6 | multiple interactions | EXP | | 6480464 | CTD | [Tetrachlorodibenzodioxin binds to and results in increased activity of AHR protein] promotes the reaction [Silicon Dioxide results in increased secretion of IL6 protein]; AHRR protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of IL6 mRNA]; F2R gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of and results in increased secretion of IL6 protein]; Lipopolysaccharides promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of IL6 mRNA]; Tetrachlorodibenzodioxin inhibits the reaction [[CpG ODN 1826 binds to and results in increased activity of TLR9 protein] which results in increased secretion of IL6 protein]; Tetrachlorodibenzodioxin inhibits the reaction [[Lipopolysaccharides binds to and results in increased activity of TLR4 protein] which results in increased secretion of IL6 protein]; Tetrachlorodibenzodioxin inhibits the reaction [EGF protein results in increased expression of IL6 mRNA]; Tetrachlorodibenzodioxin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Tetrachlorodibenzodioxin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; Tetrachlorodibenzodioxin promotes the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Tetrachlorodibenzodioxin promotes the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; Tetrachlorodibenzodioxin results in increased expression of and results in increased secretion of IL6 protein | PMID:14678569 PMID:15667827 PMID:16687389 PMID:20350561 PMID:21097750 PMID:21131560 PMID:22273745 PMID:23999131 PMID:26862745 PMID:27562557 PMID:27613713 PMID:28302560 | Il6 | decreases expression | ISO | IL6 (Homo sapiens) | 6480464 | CTD | Tetrachlorodibenzodioxin results in decreased expression of IL6 mRNA | PMID:16263508 | Il6 | increases expression | ISO | IL6 (Homo sapiens) | 6480464 | CTD | Tetrachlorodibenzodioxin results in increased expression of IL6 mRNA | PMID:18617548 PMID:21104991 PMID:23625689 PMID:28351761 | Il6 | increases expression | ISO | Il6 (Rattus norvegicus) | 6480464 | CTD | Tetrachlorodibenzodioxin results in increased expression of IL6 mRNA | PMID:33387578 | Il6 | multiple interactions | ISO | IL6 (Homo sapiens) | 6480464 | CTD | 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of IL6 mRNA]; [[IL1B protein co-treated with Tetrachlorodibenzodioxin] promotes the reaction [AHR protein binds to IL6 promoter]] which results in increased expression of IL6 mRNA; [IL1B protein co-treated with Tetrachlorodibenzodioxin] inhibits the reaction [HDAC1 protein binds to IL6 promoter]; [IL1B protein co-treated with Tetrachlorodibenzodioxin] inhibits the reaction [HDAC3 protein binds to IL6 promoter]; [IL1B protein co-treated with Tetrachlorodibenzodioxin] promotes the reaction [AHR protein binds to IL6 promoter]; [IL1B protein co-treated with Tetrachlorodibenzodioxin] promotes the reaction [NFKB1 protein binds to IL6 promoter]; [IL1B protein co-treated with Tetrachlorodibenzodioxin] promotes the reaction [RELA protein modified form binds to IL6 promoter]; [IL1B protein co-treated with Tetrachlorodibenzodioxin] results in increased expression of IL6 mRNA; [Tetrachlorodibenzodioxin co-treated with TNF protein] results in increased expression of IL6 mRNA; AHR mutant form inhibits the reaction [[IL1B protein co-treated with Tetrachlorodibenzodioxin] results in increased expression of IL6 mRNA]; AHR protein promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [IL1B protein results in increased expression of IL6 mRNA]]; AHR protein promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of IL6 mRNA]; ARNT mutant form inhibits the reaction [[IL1B protein co-treated with Tetrachlorodibenzodioxin] results in increased expression of IL6 mRNA]; HDAC1 mutant form inhibits the reaction [[IL1B protein co-treated with Tetrachlorodibenzodioxin] results in increased expression of IL6 mRNA]; HDAC3 mutant form inhibits the reaction [[IL1B protein co-treated with Tetrachlorodibenzodioxin] results in increased expression of IL6 mRNA]; IL1RN protein inhibits the reaction [[IL1B protein co-treated with Tetrachlorodibenzodioxin] results in increased expression of IL6 mRNA]; Tetrachlorodibenzodioxin inhibits the reaction [[CD40LG protein co-treated with IL2 protein co-treated with IL6 protein co-treated with IL10 protein] affects the activity of AKT1 protein]; Tetrachlorodibenzodioxin inhibits the reaction [[CD40LG protein co-treated with IL2 protein co-treated with IL6 protein co-treated with IL10 protein] affects the activity of MAPK1 protein]; Tetrachlorodibenzodioxin inhibits the reaction [[CD40LG protein co-treated with IL2 protein co-treated with IL6 protein co-treated with IL10 protein] affects the activity of MAPK3 protein]; Tetrachlorodibenzodioxin inhibits the reaction [[IL1B protein co-treated with IL6 protein] results in increased expression of SAA1 mRNA]; Tetrachlorodibenzodioxin promotes the reaction [CHUK protein binds to IL6 promoter]; Tetrachlorodibenzodioxin promotes the reaction [IL1B protein results in increased expression of IL6 mRNA] | PMID:20511231 PMID:21104991 PMID:21493753 PMID:21807014 PMID:23396138 PMID:23625689 | |
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